Entrapment of bleomycin in ultra-deformable liposomes

Entrapment of bleomycin in ultra-deformable liposomes
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DOI：
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发表时间：
2003
期刊：
Stp Pharma Sciences
影响因子：
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通讯作者：
Kent G. Lau;S. Chopra;Y. Maitani
Kent G. Lau;S. Chopra;Y. Maitani
中科院分区：
其他
文献类型：
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作者：
Kent G. Lau;S. Chopra;Y. Maitani

文献摘要

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博莱霉素被包裹在由磷脂酰胆碱和胆酸钠组成的多层脂质体（MLV）中。研究了博莱霉素 MLV 的包封效率、粒径、双层弹性和表面电荷。结果表明，脂质体制剂中胆酸钠的存在显着提高了博来霉素的包封水平，改善了双层弹性并减小了粒径。这些特征表明该制剂可能适合通过局部途径将博莱霉素递送至皮肤肿瘤。
Bleomycin was entrapped in multi-lamellar liposomes (MLVs) composed of phosphatidylcholine and sodium cholate. Entrapment efficiency, particle size, bilayer elasticity and surface charge of the bleomycin MLVs were studied. The results showed that the presence of sodium cholate in the liposome formulation significantly enhanced bleomycin entrapment levels, improved bilayer elasticity and reduced particle size. These characteristics suggest that this preparation may be suitable for delivering bleomycin to skin tumours by a topical route.