Core outcome measurement instruments for use in clinical and research settings for adults with post-COVID-19 condition: an international Delphi consensus study
Core outcome measurement instruments for use in clinical and research settings for adults with post-COVID-19 condition: an international Delphi consensus study
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用于 COVID-19 后成人临床和研究环境的核心结果测量工具：一项国际德尔菲共识研究
DOI：
10.1016/s2213-2600(23)00370-3
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Gorst S
中科院分区：
文献类型：
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作者：
Gorst S
新冠肺炎后疾病(也称为慢性冠状病毒病)是一种新的、复杂的、鲜为人知的疾病。针对成人新冠肺炎后状况的核心结果集(COS)已经制定，现在需要就这些核心结果的最适当测量工具达成一致。我们进行了一项国际共识研究，涉及多学科专家和有长期COVID生活经验的人。这项研究包括一项文献综述，以确定核心结果的衡量工具，三轮在线修改的德尔福流程，以及一次在线共识会议，以生成核心结果衡量集(COMS)。来自58个国家的594人参加了这次活动。12个核心结果的潜在工具数量从319个减少到19个。就纳入修订的医学研究理事会呼吸结果呼吸困难量表达成了共识。之前发表的急性新冠肺炎COS的两个相关结果的衡量标准也包括在内：死亡时间，生存时间，以及新冠肺炎的恢复程度，即恢复。建议考虑其余9项核心结果的指标：疲劳或精疲力竭、疼痛、劳累后症状、工作或职业和学习变化，以及心血管、神经系统、认知、心理健康和身体结果；然而，对这些结果的指标没有达成共识。建议考虑的COMS和工具为评估成人新冠肺炎后的状况提供了基础，这将有助于优化临床护理并加快全球研究。随着现有和新的测量仪器上出现新的数据，有必要对COMS进行进一步的评估。
Post-COVID-19 condition (also known as long COVID) is a new, complex, and poorly understood disorder. A core outcome set (COS) for post-COVID-19 condition in adults has been developed and agreement is now required on the most appropriate measurement instruments for these core outcomes. We conducted an international consensus study involving multidisciplinary experts and people with lived experience of long COVID. The study comprised a literature review to identify measurement instruments for the core outcomes, a three-round online modified Delphi process, and an online consensus meeting to generate a core outcome measurement set (COMS). 594 individuals from 58 countries participated. The number of potential instruments for the 12 core outcomes was reduced from 319 to 19. Consensus was reached for inclusion of the modified Medical Research Council Dyspnoea Scale for respiratory outcomes. Measures for two relevant outcomes from a previously published COS for acute COVID-19 were also included: time until death, for survival, and the Recovery Scale for COVID-19, for recovery. Instruments were suggested for consideration for the remaining nine core outcomes: fatigue or exhaustion, pain, post-exertion symptoms, work or occupational and study changes, and cardiovascular, nervous system, cognitive, mental health, and physical outcomes; however, consensus was not achieved for instruments for these outcomes. The recommended COMS and instruments for consideration provide a foundation for the evaluation of post-COVID-19 condition in adults, which should help to optimise clinical care and accelerate research worldwide. Further assessment of this COMS is warranted as new data emerge on existing and novel measurement instruments.