Evaluation of a community-based aetiological approach for sexually transmitted infections management for youth in Zimbabwe: intervention findings from the STICH cluster randomised trial.
Evaluation of a community-based aetiological approach for sexually transmitted infections management for youth in Zimbabwe: intervention findings from the STICH cluster randomised trial.
复制标题
DOI：
10.1016/j.eclinm.2023.102125
复制
发表时间：
2023-08
影响因子：
15.1
通讯作者：
Hayes, Richard J.
中科院分区：
文献类型：
--
作者：
Chikwari, Chido Dziva;Simms, Victoria;Kranzer, Katharina;Dauya, Ethel;Bandason, Tsitsi;Tembo, Mandikudza;Mavodza, Constancia;Machiha, Anna;Mugurungi, Owen;Musiyandaka, Primrose;Mwaturura, Tinashe;Tshuma, Nkazimulo;Bernays, Sarah;Mackworth-Young, Constance;Busza, Joanna;Francis, Suzanna C.;Hayes, Richard J.
年轻人感染性传播感染（STI）的风险很高。我们报告了基于社区的青少年综合艾滋病毒和性与生殖健康服务中性传播感染检测的采用情况、流行率和发病率，并在津巴布韦的一项整群随机试验中进行了评估。本文报告了整群随机试验的干预结果，该试验在 2020 年 10 月 5 日至 2021 年 12 月 17 日期间，在津巴布韦的 12 个月内向所有服务参与者（16-24 岁）提供了 12 个干预组的性传播感染检测。向男性和女性提供沙眼衣原体 [CT] 和淋病奈瑟菌 [NG] 检测，一周内即可得出结果，并通过电话对检测呈阳性的客户进行随访。仅向女性提供阴道毛滴虫 [TV] 检测，并在当天获得结果并进行治疗。任何性传播感染检测呈阳性的青少年都会获得伴侣通知单，并为伴侣提供免费治疗。该试验已在 ISRCTN 注册中心注册，ISRCTN15013425。总体而言，8549/9891 (86.1%) 符合条件的青少年接受了 CT/NG 检测。 CT 和 NG 的患病率分别为 14.7% (95% CI 13.6–15.8) 和 2.8% (95% CI 2.2–3.6)。女性 CT、NG 或 TV 的综合患病率为 23.2% (95% CI 21.5–25.0)。调整聚类、年龄和性别后，HIV 感染者的 NG 几率增加（aOR 3.14，95% CI 2.21-4.47）。最初 CT 或 NG 检测呈阴性的患者的发病率为 25.6/100PY（95% CI 20.6–31.8）。 CT/NG 治疗率为 924/1526 (60.6%)。电视治疗的接受率为 483/489 (98.8%)。一位伴侣为 103/1807 名客户 (5.7%) 回来接受治疗。我们的研究结果表明青少年对性传播感染检测的接受度很高。性传播感染的患病率很高，特别是在感染艾滋病毒的女性和青少年中，这凸显了将艾滋病毒和性传播感染服务整合起来的必要性。 /// (MR/T040327/1) 和 (206316/Z/17/Z)。
Young people are at high risk of sexually transmitted infections (STIs). We report STI testing uptake, prevalence and incidence within a community-based integrated HIV and sexual and reproductive health service for youth, being evaluated in a cluster randomised trial in Zimbabwe. This paper reports the intervention findings of the cluster randomised trial whereby STI testing was offered to all service attendees (16–24 years) in 12 intervention clusters over 12 months between October 5, 2020, and December 17, 2021, in Zimbabwe. Testing for Chlamydia trachomatis [CT] and Neisseria gonorrhoeae [NG] was offered to males and females with results available in one week and follow-up of test-positive clients by telephone. Trichomonas vaginalis [TV] testing was offered to females only with same day results and treatment. Youth testing positive for any STI were offered partner notification slips and free treatment for partners. This trial was registered with ISRCTN Registry, ISRCTN15013425. Overall, 8549/9891 (86.1%) eligible youth accepted CT/NG testing. Prevalence of CT and NG was 14.7% (95% CI 13.6–15.8) and 2.8% (95% CI 2.2–3.6) respectively. Combined prevalence of CT, NG or TV in women was 23.2% (95% CI 21.5–25.0). After adjusting for cluster, age and sex, the odds of NG were increased in those living with HIV (aOR 3.14, 95% CI 2.21–4.47). The incidence rate among those who initially tested negative for CT or NG was 25.6/100PY (95% CI 20.6–31.8). CT/NG treatment uptake was 924/1526 (60.6%). TV treatment uptake was 483/489 (98.8%). A partner returned for treatment for 103/1807 clients (5.7%). Our findings show high acceptability of STI testing among youth. STI prevalence was high particularly among females and youth with HIV, underscoring the need for integration of HIV and STI services. /// (MR/T040327/1) and (206316/Z/17/Z).
登录
查看更多内容
影响因子：
3.6
作者：
Hokororo A;Kihunrwa A;Hoekstra P;Kalluvya SE;Changalucha JM;Fitzgerald DW;Downs JA
通讯作者：
Downs JA
DOI：
10.1016/s2352-4642(20)30335-7
发表时间：
2021-03
期刊：
The Lancet. Child & adolescent health
影响因子：
--
作者：
Martin K;Olaru ID;Buwu N;Bandason T;Marks M;Dauya E;Muzangwa J;Mabey D;Dziva Chikwari C;Francis SC;Tembo M;Mavodza C;Simms V;Mackworth-Young CRS;Machiha A;Kranzer K;Ferrand RA
通讯作者：
Ferrand RA
影响因子：
--
作者：
通讯作者：
--
影响因子：
14.2
作者：
Oakeshott, P.;Kerry-Barnard, S.;Reid, F.
通讯作者：
Reid, F.
影响因子：
3.6
作者：
Wilson, Emma;Leyrat, Clemence;Free, Caroline
通讯作者：
Free, Caroline