Mechanically Adaptive Implants Fabricated with poly(2-hydroxy-ethyl methacrylate-) based negative photoresists
Mechanically Adaptive Implants Fabricated with poly(2-hydroxy-ethyl methacrylate-) based negative photoresists
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使用聚（甲基丙烯酸 2-羟乙酯）基负光刻胶制造的机械自适应植入物
DOI：
10.1039/d0tb00980f
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发表时间：
2020
影响因子：
--
通讯作者：
Monney, B.
中科院分区：
文献类型：
--
作者：
Monney, B.
基于机械自适应聚合物（MAPs）的神经植入物在植入体内后会变软，与由硅或金属制成的更坚硬的设备相比，先前已被证明能引起更少的慢性组织反应，但其可加工性受到限制。在这里，我们报告了一种负光刻胶方法，用于生理反应的map。我们利用这个框架通过光刻工艺创建了2-羟乙基甲基丙烯酸酯、2-羟乙基丙烯酸酯和2-乙基己基甲基丙烯酸酯的交联三元聚合物。我们对该平台的系统研究提供了一个优化的组合物，在干燥状态下表现出1.8 GPa的存储模量E '。暴露于模拟的生理条件下，材料轻微膨胀（21% w/w），导致E '降低至2 MPa。较大的模量变化主要是由塑化引起的，塑化使玻璃化转变从37℃以上转变到37℃以下。通过光刻技术制备的单柄探针可以很容易地植入到模拟大脑的凝胶中而不会弯曲，并且与小胶质细胞的活力研究表明该材料具有良好的生物相容性。
Neural implants that are based on mechanically adaptive polymers (MAPs) and soften upon insertion into the body have previously been demonstrated to elicit a reduced chronic tissue response than more rigid devices fabricated from silicon or metals, but their processability has been limited. Here we report a negative photoresist approach towards physiologically responsive MAPs. We exploited this framework to create cross-linked terpolymers of 2-hydroxyethyl methacrylate, 2-hydroxyethyl acrylate and 2-ethylhexyl methacrylate by photolithographic processes. Our systematic investigation of this platform afforded an optimized composition that exhibits a storage modulus E′ of 1.8 GPa in the dry state. Upon exposure to simulated physiological conditions the material swells slightly (21% w/w) leading to a reduction of E′ to 2 MPa. The large modulus change is mainly caused by plasticization, which shifts the glass transition from above to below 37 °C. Single shank probes fabricated by photolithography could readily be implanted into a brain-mimicking gel without buckling and viability studies with microglial cells show that the materials display excellent biocompatibility.