Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors
Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors
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DOI：
10.1179/135100003225003393
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发表时间：
2003-01-01
期刊：
影响因子：
3.8
通讯作者：
Palasodkar, R
中科院分区：
文献类型：
--
作者：
Khanzode, SD;Dakhale, GN;Palasodkar, R
有证据表明，抑郁症的氧化和抗氧化防御系统紊乱。本研究探讨了氟西汀和西酞普兰，标准的选择性5-羟色胺再摄取抑制剂，对脂质过氧化，超氧化物歧化酶（SOD）的活性和抗坏血酸浓度的影响。为此，采用了前瞻性、开放标签、随机设计。将抑郁症患者（n=62）与年龄和性别匹配的健康志愿者（n=40）进行比较。与对照组相比，抑郁症患者血清SOD、MDA水平显著升高，血浆抗坏血酸水平显著降低。氟西汀和西酞普兰治疗后，这一趋势明显逆转。结果表明，西酞普兰比氟西汀更能降低氧化应激。氟西汀和西酞普兰治疗后，汉密尔顿抑郁量表（HRSD）评分也有所改善。提示抑郁症与血清SOD、MDA水平升高及血浆抗坏血酸水平降低有关。氟西汀和西酞普兰治疗逆转了这些生化参数。本研究可作为氟西汀和西酞普兰治疗抑郁症疗效的预测指标。
There is evidence of derangement of oxidant and antioxidant defense systems in depression. The present study examined the effects of fluoxetine and citalopram, standard selective serotonin re-uptake inhibitors, on lipid peroxidation, superoxide dismutase (SOD) activity and ascorbic acid concentrations. For this, a prospective open-labeled, randomized design was utilized. Patients with major depression (n=62) were compared with age- and sex-matched healthy volunteers (n=40). There was a significant increase in serum SOD, serum MDA and decrease in plasma ascorbic acid levels in patients of major depression as compared to control subjects. The trend reversed significantly after treatment with fluoxetine and citalopram. Results indicate a greater reduction in oxidative stress with citalopram than fluoxetine. The Hamilton Rating Scale for Depression (HRSD) score also improved with fluoxetine and citalopram treatment. These findings indicate that major depression is associated with increased levels of serum SOD, serum MDA and decreased levels of plasma ascorbic acid. Treatment with fluoxetine and citalopram reversed these biochemical parameters. This study can be used as a predictor of drug response by fluoxetine and citalopram in major depression.