Comparison of Clinical and Pathological Staging in Head and Neck Squamous Cell Carcinoma Results From Intergroup Study ECOG 4393/RTOG 9614
Comparison of Clinical and Pathological Staging in Head and Neck Squamous Cell Carcinoma Results From Intergroup Study ECOG 4393/RTOG 9614
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DOI：
10.1001/archoto.2009.123
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发表时间：
2009-09-01
影响因子：
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通讯作者：
Manola, Judith
中科院分区：
文献类型：
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作者：
Koch, Wayne M.;Ridge, John A.;Manola, Judith
目的：比较头颈部鳞状细胞癌（HNSCC）患者的临床和病理分期结果，并研究不同分期方法之间的差异模式和后果。设计：前瞻性初始队列（中位随访时间为7年）。多机构合作小组研究（东部肿瘤协作组4393/放射治疗肿瘤组9614），涉及17个学术医疗中心。共560例新发或复发的HNSCC患者在7年期间入组。干预措施：手术切除与根治性意图，有或没有辅助或以前的放疗或化疗。主要结果指标：比较临床分期、病理分期及TN肿瘤分类与总生存率和疾病特异性生存率。协会的生存期与分期是通过比例风险model.Results：在501例中，临床和病理分期是可用的，一个差距被发现之间至少有1个组件的肿瘤类别分配的两种方法在几乎50%的情况下。这两种方法都显示了大规模队列的分期与总生存率的强相关性。而病理类型是一个较好的上级预测因子（P
Objectives: To compare the results of clinical and pathological staging for a large cohort of patients with head and neck squamous cell carcinoma (HNSCC) and to examine patterns and ramifications of the disparity between staging methods.Design: Prospective inception cohort (median follow-up, 7 years).Setting: Multi-institutional cooperative group study (Eastern Cooperative Oncology Group 4393/Radiation Therapy Oncology Group 9614) involving 17 academic medical centers.Patients: A total of 560 patients with new-onset or recurrent HNSCC enrolled during a 7-year period.Interventions: Surgical resection with curative intent with or without adjuvant or previous radiotherapy or chemotherapy.Main Outcome Measures: Clinical staging and pathological staging and the component TN tumor categorieswere compared with overall and disease-specific Survival. Association of survival With staging was derived by means Of the proportional hazards model.Results: Of the 501 cases in which both clinical and pathological staging was available, a disparity was found between at least 1 component tumor category assigned by the 2 methods in almost 50% of cases. Both methods showed a strong association of stage with overall survival for the cohort at large. However, pathological nodal category was a superior predictor (P