Prevalence of asthma-like symptoms in young children
Prevalence of asthma-like symptoms in young children
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DOI：
10.1002/ppul.20644
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发表时间：
2007-08-01
影响因子：
3.1
通讯作者：
Szefler, Stanley
中科院分区：
文献类型：
--
作者：
Bisgaard, Hans;Szefler, Stanley
目的确定美国和欧洲学龄前儿童哮喘样症状的患病率、影响和治疗。研究设计：在美国和欧洲的7251个家庭中，至少有一个1 - 5岁的孩子，通过电话采访了在最近6个冬季的几个月里反复出现咳嗽，喘息或呼吸困难的日子。结果如下：9490名幼儿被确定，其中32%的人被报告患有反复出现的咳嗽，喘息或呼吸困难。对2700名有症状儿童的母亲进行的详细访谈显示，尽管目前的治疗对生活方式和医疗资源的使用产生了相当大的影响，但24%的受访人群每周都会出现症状。抗生素、咳嗽和草药是最常用的治疗方法。抗哮喘和抗过敏药物的处方顺序为：吸入性β 2受体激动剂>吸入性皮质类固醇>口服抗组胺药>口服皮质类固醇。报告的症状负担在南欧较高，在治疗和诊断方面存在明显的区域差异。结论：学龄前儿童咳嗽、喘息或呼吸困难的反复发作是学龄前儿童发病的主要原因，尽管目前有治疗。在诊断和治疗方面缺乏国际共识。这种不受控制的发病率突出了学龄前儿童中显著未满足的临床需求。
Objective To determine the prevalence, impact, and treatment of asthma-like symptoms in preschool children in USA and Europe. Study Design: 7251 households in USA and Europe with at least one child aged 1 -5 years were interviewed by telephone for recurrent days troubled by cough, wheeze or breathlessness during the recent 6 winter months. Results: 9490 young children were identified, 32% of whom were reported to suffer from recurrent days with troublesome cough, wheeze or breathlessness. Detailed interview with the 2700 mothers of the symptomatic children showed that 24% of this interview population suffered weekly symptoms despite current treatment with considerable impact on lifestyle and healthcare resource use. Antibiotics, cough- and herbal-medications were the most commonly used treatments. Antiasthmatic and anti-allergy agents were prescribed in the order: inhaled beta(2)-agonists > inhaled corticosteroid > oral anti-histamines > oral corticosteroids. The reported symptom burden was higher in Southern Europe and there were pronounced regional differences in treatment and diagnostic terms. Conclusions: Recurrent days with cough, wheeze or breathlessness in preschool children represents a major cause of morbidity in preschool children despite current treatment. There is a striking lack of international consensus on diagnosis and treatment. This uncontrolled morbidity highlights a significant unmet clinical need in preschool children.