Normal liver stiffness: a study in living donors with normal liver histology
Normal liver stiffness: a study in living donors with normal liver histology
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DOI：
10.4254/wjh.v7.i8.1149
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发表时间：
2015-05-18
影响因子：
2.4
通讯作者：
Waked, Imam
中科院分区：
文献类型：
--
作者：
Alsebaey, Ayman;Allam, Naglaa;Waked, Imam
目的：在肝组织学正常的活体肝移植候选供体中使用瞬时弹性成像来确定肝硬度（LS）值的正常范围。使用Fibroscan在50例患者中测量LS（16名女性，34名男性）健康的潜在供体（平均年龄28.4 +/- 5.9岁），他们正在埃及Menoufeya大学国家肝脏研究所为其亲属进行肝脏捐赠评估。所有潜在供体的肝脏检查均正常，且B或C型肝炎病毒感染均为阴性。腹部超声检查结果正常。所有受试者均无糖尿病、高血压、肾损害、心脏病或体重指数> 30 kg/m2。所有受试者在肝活检时均具有正常的肝组织学。结果：平均LS为4.3 ± 1.2 kPa（范围：1.8-7.1 kPa）。正常LS的第5次和第95次测量值分别为2.6 kPa和6.8 kPa，中位数为4 kPa;四分位距为0.6 +/- 0.4。LS测量值在男性和女性之间没有显著差异（4.4 +/- 1.1 kPa vs 3.9 +/- 1.3 kPa），并且与年龄无关。然而，与体重指数>= 26 kg/m2的受试者相比，体重指数< 26 kg/m2的受试者的僵硬度值显著降低（4.0 +/- 1.1 kPa vs 4.6 +/- 1.2 kPa; P < 0.05）。在肝硬度= 4 kPa和硬度> 4 kPa的供体之间，住院时间或术后胆红素、白蛋白、丙氨酸和天冬氨酸转氨酶或肌酐水平（出院时）无差异。结论：肝组织学正常的健康供体的LS中位数为4 kPa。刚度值相对于体重指数的增加而升高。
AIM: To define the normal range of liver stiffness (LS) values using transient elastography in living-related liver transplantation candidate donors with normal liver histology.METHODS: LS was measured using Fibroscan in 50 (16 women, 34 men) healthy potential donors (mean age 28.4 +/- 5.9 years) who were being evaluated for liver donation for their relatives at the National Liver Institute, Menoufeya University, Egypt. All potential donors had normal liver tests and were negative for hepatitis B or C virus infection. Abdominal ultrasounds showed normal findings. None of the subjects had diabetes, hypertension, renal impairment, heart disease, or body mass index > 30 kg/m(2). All subjects had normal liver histology upon liver biopsy. They all donated the right lobe of their liver with successful outcomes.RESULTS: The mean LS was 4.3 +/- 1.2 kPa (range: 1.8-7.1 kPa). The 5th and 95th percentiles of normal LS were 2.6 kPa and 6.8 kPa, respectively, with a median of 4 kPa; the interquartile range was 0.6 +/- 0.4. LS measurements were not significantly different between men and women (4.4 +/- 1.1 kPa vs 3.9 +/- 1.3 kPa) and did not correlate with age. However, stiffness values were significantly lower in subjects with a body mass index < 26 kg/m(2) compared to those with an index >= 26 kg/m(2) (4.0 +/- 1.1 kPa vs 4.6 +/- 1.2 kPa; P < 0.05). There were no differences in hospital stay or postoperative bilirubin, albumin, alanine and aspartate transaminases, or creatinine levels (at discharge) between donors with livers stiffness = 4 kPa and those with stiffness > 4 kPa.CONCLUSION: Healthy donors with normal liver histology have a median LS of 4 kPa. Stiffness values are elevated relative to increase in body mass index.