Increased Hepatic Iron Content Predicts Poor Survival in Patients With Iron Overload Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation.
Increased Hepatic Iron Content Predicts Poor Survival in Patients With Iron Overload Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation.
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DOI：
10.1016/j.clml.2016.02.005
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发表时间：
2016-08
期刊：
影响因子：
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通讯作者：
S. Şıvgın;S. Baldane;K. Deniz;G. Zararsiz;L. Kaynar;M. Çetin;A. Unal;B. Eser
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文献类型：
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作者：
S. Şıvgın;S. Baldane;K. Deniz;G. Zararsiz;L. Kaynar;M. Çetin;A. Unal;B. Eser
目的异基因造血干细胞移植（alloHSCT）受者铁超载导致感染、静脉闭塞性疾病和肝功能障碍增加。肝脏是最常见的网站之一的铁overload.Patients和MethodsA共50 alloHSCT接受者，在Erciyes干细胞移植医院，Erciyes大学，2004年和2011年之间进行了肝活检入组的研究。肝活检标本取自Erciyes大学病理学系档案室，并进行铁含量染色。中位总生存期（OS）：53个月（最小值-最大值：41-65），0级患者，55个月（最小值-最大值：47-64）1级患者，2级患者25.4个月（11.5-39.4），3级患者29.3个月（最小值-最大值：12.3-46.3），4级患者2.6个月（最小值-最大值：2.0-3.3）。总生存率与肝脏铁含量的程度相关，Kaplan-Meier分析有统计学意义（P<0.001）。发现无病生存期（DFS）; 0级患者47.1个月（最小值-最大值：32.0-62.0），1级患者36.9个月（最小值-最大值：21.0-65.0），2级患者23.5个月（最小值-最大值：12.0-59.0），3级患者27.4个月（最小值-最大值：5.3-59.3），4级患者2.6个月（最小值-最大值：2.0-3.0）。外勤支助部; Kaplan-Meier分析显示，肝铁超载与接受alloHSCT的输血性铁超载患者的生存率相关（P= 0.093）。结论肝铁含量可能与接受alloHSCT的铁超载患者的预后不良相关。
AimIron overload results in increased infection, venous-oclusive disease and hepatic dysfunction in allogeneic hematopoietic stem cell transplant (alloHSCT) recipients. Liver is one of the most common sites of iron overload.Patients and MethodsA total of 50 alloHSCT recipients that underwent liver biopsy in Erciyes Stem Cell Transplantation Hospital, Erciyes University, between 2004 and 2011 were enrolled in the study. The liver biopsy specimens have been obtained from the archives of Erciyes University, Department of Pathology and stainned for iron content.ResultsThe mean age was found 34 ± 11 years. For median overall survival (OS); 53 months (min-max: 41-65) in patients with grade 0, 55 months (min-max: 47-64) in patients with grade 1, in patients with grade 2 patients 25.4 months (11.5-39.4 ), grade 3 patients 29.3 months (min-max: 12.3-46.3) and grade 4 patients 2.6 months (min-max: 2.0-3.3). Overall survival was correlated with the degree of liver iron content and it was statistically significant in Kaplan-Meier analysis (P< .001). Disease-free survival was found (DFS); grade 0 patients 47.1 months (min-max: 32.0-62.0), grade 1 patients 36.9 months (min-max: 21.0-65.0), grade 2 patients 23.5 months (min-max: 12.0-59.0), grade 3 patients 27.4 months (min-max: 5.3-59.3) and grade 4 patients 2.6 months (min-max: 2.0-3.0). For DFS; it was negatively correlated with the degree of liver iron content nevertheless; it was not was statistically significant in Kaplan-Meier analysis (P= .093).Hepatic iron overload might be associated with poor survival in patients with transfusional iron overload that underwent alloHSCT.ConclusionHepatic iron content might be associated with poorer prognosis in patients with iron overload that underwent alloHSCT.