Branchial elimination of superhydrophobic organic compounds by rainbow trout (Oncorhynchus mykiss)
Branchial elimination of superhydrophobic organic compounds by rainbow trout (Oncorhynchus mykiss)
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DOI：
10.1016/s0166-445x(01)00174-6
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发表时间：
2001-11-01
影响因子：
4.5
通讯作者：
Nichols, JW
中科院分区：
文献类型：
--
作者：
Fitzsimmons, PN;Fernandez, JD;Nichols, JW
使用鱼呼吸计代谢室和吸附树脂柱测量虹鳟鱼鳃消除五氯乙烷和四种同源多氯联苯的情况。通过计算一组表观体内血液：水分配系数（P-BW）来表征鳃消除。对每种化合物的 P-BW 估计值的对数和 log K-OW 值进行线性回归，得到拟合方程：109 P-BW = 0.76-log K-OW - 1.0 (r(2) = 0.98)。这种关系的线性性质为现有的鱼鳃化学通量模型提供了支持，并表明进入鳃的静脉血中的化学物质（包括溶解和结合形式）与呼出的鳃水中溶解的化学物质之间建立了接近平衡的条件。将体内 P-BW 估计值与体外测定的一组较低 log Kw 化合物的 P-BW 值相结合（Bertelson 等人，Environ. Toxicol. Chem. 17 (1998) 1447-1455），得出拟合关系：log P-BW = 0.73-log K-OW - 0.88 (r(2) = 0.98)，该方程的斜率与与非脂质有机物质的化学结合对血液：水的化学分配有很大贡献的建议。然后导出基于鳟鱼血液成分（水含量和有机物质总量）的方程，以预测 log K-OW 值范围从 0 到 8 的化合物的血液：水分配：log P-BW = log [(10(0.73 log KOW.)0.16) + 0.84]，由 Elsevier Science BN 出版。
The branchial elimination of pentachloroethane and four congeneric polychlorinated biphenyls by rainbow trout was measured using a fish respirometer-metabolism chamber and an adsorption resin column. Branchial elimination was characterized by calculating a set of apparent in vivo blood:water partition coefficients (P-BW). Linear regression was performed on the logarithms of P-BW estimates and the log K-OW value for each compound to give the fitted equation: 109 P-BW = 0.76-log K-OW - 1.0 (r(2) = 0.98). The linear nature of this relationship provides support for existing models of chemical flux at fish gills and suggests that a near equilibrium condition was established between chemical in venous blood entering the gills, including dissolved and bound forms, and dissolved chemical in expired branchial water. In Vivo P-BW estimates were combined with P-BW values determined in vitro for a set of lower log Kw compounds (Bertelson et al., Environ. Toxicol. Chem. 17 (1998) 1447-1455) to give the fitted relationship: log P-BW = 0.73-log K-OW - 0.88 (r(2) = 0.98), The slope of this equation is consistent with the suggestion that chemical binding to non-lipid organic material contributes substantially to blood:water chemical partitioning. An equation based on the composition of trout blood (water content and the total amount of organic material) was then derived to predict blood:water partitioning for compounds with log K-OW values ranging from 0 to 8: log P-BW = log [(10(0.73 log KOW.)0.16) + 0.84], Published by Elsevier Science BN.