p53 Gene Mutations in Human Prostate Cancers in Japan: Different Mutation Spectra between Japan and Western Countries
p53 Gene Mutations in Human Prostate Cancers in Japan: Different Mutation Spectra between Japan and Western Countries
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日本人类前列腺癌中的 p53 基因突变：日本与西方国家的突变谱不同
DOI：
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
M. Nagao
中科院分区：
文献类型：
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作者：
Masatoshi Watanabe;T. Ushijima;H. Kakiuchi;T. Shiraishi;R. Yatani;J. Shimazaki;T. Kotake;T. Sugimura;M. Nagao
在日本研究了p53突变与前列腺癌的关系。为了评估任何可能的临床病理意义，我们采用聚合酶链反应-单链构象多态性（PCR - SSCP）分析和测序方法，检测了36例日本前列腺癌不同分期（5例潜伏性肿瘤，3例A期癌症，10例B期癌症，5例C期癌症和13例D期癌症）的40例样本中的p53突变，包括4例D期淋巴结转移病例。40份样本中有5份（12.5%）检测到突变；其中四人患有原发性癌症，另一人患有其中一种癌症的淋巴结转移。所有突变阳性病例均为D期，D期病例的突变频率为31%。这一结果表明p53突变可能在日本前列腺癌亚群的进展中发挥作用，正如在美国和欧洲所观察到的那样。然而，日本人和美国人在p53突变谱（CpG位点）上存在差异，这可能是由潜在病因因素的差异引起的。
The involvement of p53 mutations in prostate cancers in Japan was investigated. To evaluate any possible clinicopathological significance, p53 mutations in 40 samples from 36 Japanese prostate cancers of different stages (five cases of latent tumors, three of stage A cancers, 10 of stage B, five of stage C and 13 of stage D), including four lymph node metastases of stage D cases, were examined by polymerase chain reaction‐single strand conformation polymorphism (PCR‐SSCP) analysis and sequencing. Mutations were detected in five of 40 samples (12.5%); four were in primary cancers and the other in a lymph node metastasis from one of them. All mutation‐positive cases were in stage D, and the mutation frequency in stage D cases was 31%. This result indicates that p53 mutations may play a role in the progression of a subgroup of prostate cancers in Japanese, as observed for Americans and Europeans. However, a difference was noted between Japanese and Americans in the p53 mutational spectrum (at CpG site), presumably arising from variation in the underlying etiotogic factors.
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影响因子：
11.2
作者：
Robert;Bookstein;D. Macgrogan;S. Hilsenbeck;F. Sharkey;D. Allred
通讯作者：
Robert;Bookstein;D. Macgrogan;S. Hilsenbeck;F. Sharkey;D. Allred
DOI：
10.1073/pnas.91.1.360
发表时间：
1994-01-04
影响因子：
11.1
作者：
NAKAZAWA, H;ENGLISH, D;YAMASAKI, H
通讯作者：
YAMASAKI, H
影响因子：
56.9
作者：
WINK, DA;KASPRZAK, KS;KEEFER, LK
通讯作者：
KEEFER, LK
影响因子：
11.2
作者：
B. Carter;J. I. Epstein;W. Isaacs
通讯作者：
B. Carter;J. I. Epstein;W. Isaacs
影响因子：
56.9
作者：
HOLLSTEIN, M;SIDRANSKY, D;HARRIS, CC
通讯作者：
HARRIS, CC