Plasma fibrinogen and serum C-reactive protein are associated with non-small cell lung cancer
Plasma fibrinogen and serum C-reactive protein are associated with non-small cell lung cancer
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DOI：
10.1016/j.lungcan.2006.03.012
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发表时间：
2006-07-01
期刊：
影响因子：
5.3
通讯作者：
Graham, Alastair N.
中科院分区：
文献类型：
--
作者：
Jones, J. Mark;McGonigle, Niall C.;Graham, Alastair N.
目的：凝血功能与肺癌的发生有关。因此，术前血浆纤维蛋白原和血清C-反应蛋白（CRP）浓度进行评估，以确定其与肿瘤特征的关联，并确定在患者选择根治性切除术的任何rote.Methods：这些参数进行了比较，肿瘤大小，pTNM分期，并在93例非小细胞肺癌谁接受手术切除的完全切除的可能性。血浆纤维蛋白原浓度（r（s）=0.34，P=0.001）和血清CRP浓度（r（s）=0.34，P=0.001）与最大病理肿瘤大小呈正相关。与腺癌相比，鳞状细胞癌患者的血浆纤维蛋白原浓度更高（4.5 +/- 0.13 g/L vs 3.6 +/- 0.28 g/L; P = 0.008），CRP的趋势相似（P=0.06）。病理T分期也与平均血浆纤维蛋白原和血清CRP浓度相关（分别为P=0.01和0.04），但pN分期与这两个参数均无关。血浆纤维蛋白原> 5 g/L或血清CRP > 40 mg/L的患者中，23%的患者发生不完全切除（而血浆纤维蛋白原> 5 g/L或血清CRP > 40 mg/L的患者仅为8%）。
Objectives: There is an association between coagulation and lung cancer. Therefore, preoperative plasma fibrinogen and serum C-reactive protein (CRP) concentration were assessed to determine their association with tumour characteristics and to ascertain any rote in patient selection for curative resection.Methods: These parameters were compared with tumour size, pTNM stage, and possibility of complete resection in 93 patients with non-small cell lung cancer who underwent surgical resection.Results: Plasma fibrinogen concentration (r(s)=0.34, P=0.001) and serum CRP concentration ((r(s)=0.34, P=0.001) were positively correlated with maximum pathological tumour size. A higher plasma fibrinogen concentration was associated with squamous cell carcinoma versus adenocarcinorna (4.5 +/- 0.13 g/L versus 3.6 +/- 0.28 g/L; P = 0.008), with a trend towards a similar association for CRP (P=0.06). Pathological T stage was also associated with mean plasma fibrinogen and serum CRP concentration (P=0.01 and 0.04, respectively), but pN stage was not associated with either parameter. Incomplete resection occurred in 23% of patients with plasma fibrinogen > 5 g/L or serum CRP > 40mg/L (versus only 8% when fibrinogen