Associations of gestational diabetes, existing diabetes, and glycosuria with offspring obesity and cardiometabolic outcomes.
Associations of gestational diabetes, existing diabetes, and glycosuria with offspring obesity and cardiometabolic outcomes.
复制标题
妊娠糖尿病，现有糖尿病和糖尿的关联与后代肥胖和心脏代谢结果的关联。
DOI：
10.2337/dc11-1633
复制
发表时间：
2012-01
期刊：
影响因子：
16.2
通讯作者：
Lawlor DA
中科院分区：
文献类型：
--
作者：
Patel S;Fraser A;Davey Smith G;Lindsay RS;Sattar N;Nelson SM;Lawlor DA
评估妊娠期糖尿病、现有糖尿病和糖尿与青春期后代肥胖和心脏代谢危险因素的关系。在前瞻性妊娠队列中进行多变量回归分析（不同结局的n = 2，563 - 4，198）。产科数据从临床记录中提取。在平均年龄15.5岁时评估后代结局。与失访者相比，纳入分析的参与者的社会经济地位较高。结果包括BMI、腰围、通过双能X线吸收扫描测定的脂肪量、收缩压和舒张压（分别为sBP和DBP）、空腹血糖、胰岛素、血脂和C反应蛋白（CRP）。母亲现有的糖尿病、妊娠期糖尿病和糖尿与后代较高的BMI和脂肪质量（z评分）相关;然而，在混杂因素校正模型中，这种影响减弱，CI包括零值。现有糖尿病和妊娠期糖尿病与后代较高的空腹血糖水平相关（分别为0.24 mmol/L [95% CI 0.03-0.45]和0.20 mmol/L [0.02-0.39]）。糖尿与较高的空腹胰岛素相关（校正后的几何均值比为1.12 [1.01-1.25]），但现有或妊娠期糖尿病与后代空腹胰岛素无明显相关性。几乎没有证据表明母亲糖尿病或糖尿与后代DBP、sBP、血脂或CRP相关。孕产妇妊娠糖尿病、妊娠期糖尿病和现有糖尿病显示出与青春期评估的较高后代空腹血糖和胰岛素有一些相关性，但与更广泛的心脏代谢危险因素没有明显相关性。
To assess associations of gestational diabetes, existing diabetes, and glycosuria with adiposity and cardiometabolic risk factors in offspring at adolescence. Multivariable regression analyses were conducted in a prospective pregnancy cohort (n = 2,563–4,198 for different outcomes). Obstetric data were abstracted from clinical records. Offspring outcomes were assessed at mean age 15.5 years. Compared with those lost to follow-up, participants included in the analysis were of higher socioeconomic position. Outcomes included BMI, waist circumference, fat mass determined by dual-energy X-ray absorptiometry scan, systolic and diastolic blood pressure (sBP and dBP, respectively), fasting glucose, insulin, lipids, and C-reactive protein (CRP). Maternal existing diabetes, gestational diabetes, and glycosuria were associated with higher offspring BMI and fat mass (z scores); however, this effect was attenuated in the confounder-adjusted model, and the CIs included the null value. Existing diabetes and gestational diabetes were associated with higher offspring fasting glucose levels (0.24 mmol/L [95% CI 0.03–0.45] and 0.20 mmol/L [0.02–0.39], respectively). Glycosuria was associated with higher fasting insulin (adjusted ratio of geometric means 1.12 [1.01–1.25]), but there were no clear associations of existing or gestational diabetes with offspring fasting insulin. There was little evidence of an association of maternal diabetes or glycosuria with offspring dBP, sBP, lipids, or CRP. Maternal pregnancy glycosuria, gestational diabetes, and existing diabetes show some associations with higher offspring fasting glucose and insulin assessed in adolescence but are not clearly associated with a wider range of cardiometabolic risk factors.