Macular Ganglion Cell and Retinal Nerve Fiber Layer Thickness in Children With Refractive Errors-An Optical Coherence Tomography Study
Macular Ganglion Cell and Retinal Nerve Fiber Layer Thickness in Children With Refractive Errors-An Optical Coherence Tomography Study
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DOI：
10.1097/ijg.0000000000000683
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发表时间：
2017-07-01
影响因子：
2
通讯作者：
Ngo, Cheryl
中科院分区：
文献类型：
--
作者：
Goh, Jody P.;Koh, Victor;Ngo, Cheryl
目的：为研究屈光不正儿童黄斑神经节细胞-内丛状层（GC-IPL）厚度和视乳头周围视网膜神经纤维层（RNFL）厚度的分布，材料与方法：选取国立大学附属医院眼科门诊屈光不正儿童139例243只健康眼，屈光不正范围为-10.00 ~+5.00D。在全面的眼部检查、屈光和眼轴长度（AL）测量（IOLMaster）后，使用光谱域Cirrus高清光学相干断层扫描系统（Carl Zeiss Meditec Inc.）获得黄斑GC-IPL和RNFL厚度值。仅包括信号强度>6/10的扫描。使用Pearson相关系数计算变量之间的相关性。结果：平均等效球镜屈光度为-3.20 +/- 3.51D，平均AL为24.39 +/- 1.72mm。平均值、最小值、上级值和劣质GC-IPL分别为82.59 +/- 6.29、77.17 +/- 9.65、83.68 +/- 6.96和81.64 +/- 6.70 μ m。平均、上级和下级乳头周围RNFL分别为99.00垂直于11.45、123.20垂直于25.81和124.24 +/- 22.23 μ m。平均、上级和低级GC-IPL与AL相关（β =-2.056，P值0.000; β =-2.383，P值0.000; β =-1.721，P值0.000），但最小GC-IPL与AL无关（β =-1.056，P值0.115）。结论：本研究建立了屈光不正儿童黄斑GC-IPL和RNFL厚度的正常值。我们的研究结果表明，高清晰度光学相干断层扫描RNFL参数和最小GC-IPL不受AL或儿童近视的影响，因此需要进一步评估儿童青光眼患者。
Purpose: To study the distribution of macular ganglion cell-inner plexiform layer (GC-IPL) thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in children with refractive errors.Materials and Methods: Two hundred forty-three healthy eyes from 139 children with refractive error ranging from -10.00 to +5.00D were recruited from the National University Hospital Eye Surgery outpatient clinic. After a comprehensive ocular examination, refraction, and axial length (AL) measurement (IOLMaster), macular GC-IPL and RNFL thickness values were obtained with a spectral domain Cirrus high definition optical coherence tomography system (Carl Zeiss Meditec Inc.). Only scans with signal strength of >6/10 were included. Correlation between variables was calculated using the Pearson correlation coefficient. A multivariate analysis using mixed models was done to adjust for confounders.Results: The mean spherical equivalent refraction was -3.20 +/- 3.51D and mean AL was 24.39 +/- 1.72mm. Average, minimum, superior, and inferior GC- IPL were 82.59 +/- 6.29, 77.17 +/- 9.65, 83.68 +/- 6.96, and 81.64 +/- 6.70 mu m, respectively. Average, superior, and inferior peripapillary RNFL were 99.00 perpendicular to 11.45, 123.20 perpendicular to 25.81, and 124.24 +/- 22.23 mu m, respectively. Average, superior, and inferior GC-IPL were correlated with AL (beta = -2.056, P-value 0.000; beta = -2.383, P- value 0.000; beta = -1.721, P-value 0.000), but minimum GC- IPL was not (beta = -1.056, P-value 0.115). None of the RNFL parameters were correlated with AL.Conclusions: This study establishes normative macular GC- IPL and RNFL thickness in children with refractive errors. Our results suggest that high definition optical coherence tomography RNFL parameters and minimum GC-IPL are not affected by AL or myopia in children, and therefore warrants further evaluation in pediatric glaucoma patients.