Central hyperexcitability in fibromyalgia
Central hyperexcitability in fibromyalgia
复制标题
纤维肌痛中枢过度兴奋
DOI：
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
L. Arendt
中科院分区：
文献类型：
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作者：
T. Graven‐Nielsen;J. Sörensen;K. Henriksson;M. Bengtsson;L. Arendt
纤维肌痛患者存在对压力刺激的痛觉过敏和自发性肌肉痛。如果在没有自发性疼痛的肌肉中发现对疼痛刺激的反应增加，则可能表明FMS涉及中枢兴奋过度。在本研究中，FMS患者无痛肌肉的实验性疼痛刺激导致与对照组相比夸张的牵涉性疼痛模式。此外，与对照组相比，重复的疼痛性电肌肉刺激导致FMS患者的易化疼痛[即，增加时间总和的增益]。疼痛肌肉上方皮肤刺激的时间总和不受影响。这些发现可能反映了FMS患者中枢兴奋过度[肌肉痛觉过敏]的参与。
SUMMARYHyperalgesia to pressure stimuli combined with spontaneous muscle pain are present in fibromyalgia [FMS]. If increased responses to painful stimuli are found in muscles without spontaneous pain, it could indicate involvement of central hyperexcitability in FMS. In the present study, experimental painful stimulation of a pain-free muscle in FMS patients resulted in exaggerated referred pain patterns compared to controls. Moreover, repeated painful electrical muscle stimulation caused facilitated pain in FMS patients compared to controls [i.e., increased gain of temporal summation]. Temporal summation of skin stimuli above the painful muscle was not affected. These findings probably reflect involvement of central hyperexcitability [muscular hyperalgesia] in the FMS patients.
影响因子：
5.5
作者：
LAMOTTE, RH;LUNDBERG, LER;TOREBJORK, HE
通讯作者：
TOREBJORK, HE