Diclofenac and enolicam as ocular anti-inflammatory drugs in rabbit corneal wound model.
Diclofenac and enolicam as ocular anti-inflammatory drugs in rabbit corneal wound model.
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双氯芬酸和烯醇康作为眼部抗炎药用于兔角膜伤口模型。
DOI：
10.1089/jop.1986.2.171
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Srinivasan,BD
中科院分区：
文献类型：
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作者：
Kulkarni,P;Srinivasan,BD
在兔角膜创伤模型上，评价了两种非甾体类药物依诺康和双氯芬酸的抗炎作用。局部应用0.01%、0.1%和0.5%浓度的双氯芬酸（50 μl体积）可抑制家兔部分（6 mm中心区域）角膜深上皮化后多形核白细胞（PMN）释放到泪液中。同样，enolicam也能抑制角膜损伤后的PMN反应。局部双氯芬酸比局部依诺康更有效地抑制部分角膜损伤后的炎性PMN反应。两种药物均不影响完全（角膜缘至角膜缘）角膜深上皮化后的上皮再形成率。
The anti-inflammatory effects of two nonsteroidal agents, enolicam and diclofenac, were assessed in rabbit corneal wound model. Topically applied diclofenac (50 μl volume) at 0.01%, 0.1% and 0.5% concentrations inhibited the polymorphonuclear leukocyte (PMN) release into tear fluid following partial (6 mm central area) corneal deepithelialization in rabbits. Similarly, enolicam also inhibited this PMN response following corneal injury. Topical diclofenac was found to be more potent than topical enolicam in inhibiting the inflammatory PMN response following partial corneal injury. Both drugs did not affect the rate of reepithelialization following complete (limbal to limbal) corneal deepithelialization.