Investigation of the source‐detector separation in near infrared spectroscopy for healthy and clinical applications
Investigation of the source‐detector separation in near infrared spectroscopy for healthy and clinical applications
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DOI：
10.1002/jbio.201900175
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发表时间：
2019-07
影响因子：
2.8
通讯作者：
Lei Wang;H. Ayaz;M. Izzetoglu
中科院分区：
文献类型：
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作者：
Lei Wang;H. Ayaz;M. Izzetoglu
了解近红外光在组织中的传播对设计下一代光学脑成像设备至关重要。蒙特卡罗（MC）模拟提供了一种受控机制来表征和评估不同近红外光谱（NIRS）传感器配置和参数的贡献。在这项研究中，我们在健康和临床环境下建立了一个多层成人数字头部模型，并通过MC模拟评估光与组织的相互作用，包括偏微分光路长度、平均总光路长度、漫反射、探测器光强和光学测量的空间灵敏度分布。该模型包含四层：头皮、颅骨、脑脊液和大脑皮层，有或没有可定制的病变，以模拟不同大小和深度的血肿。研究了源检测器分离（SDS）对光学测量脑组织灵敏度的影响。1330个单独的模拟结果[（临床4个病变体积× 4个病变深度+3个健康环境）× 7个SDS × 10个模拟= 1330)]，每个1亿个光子表明，SDS的选择对于获得最佳的大脑测量至关重要，建议SDS为25至35 mm，具体取决于波长，以获得成人脑功能的光学监测。这些发现可以指导未来NIRS探针用于功能神经成像和临床诊断系统的设计。
Understanding near infrared light propagation in tissue is vital for designing next generation optical brain imaging devices. Monte Carlo (MC) simulations provide a controlled mechanism to characterize and evaluate contributions of diverse near infrared spectroscopy (NIRS) sensor configurations and parameters. In this study, we developed a multilayer adult digital head model under both healthy and clinical settings and assessed light‐tissue interaction through MC simulations in terms of partial differential pathlength, mean total optical pathlength, diffuse reflectance, detector light intensity and spatial sensitivity profile of optical measurements. The model incorporated four layers: scalp, skull, cerebrospinal‐fluid and cerebral cortex with and without a customizable lesion for modeling hematoma of different sizes and depths. The effect of source‐detector separation (SDS) on optical measurements' sensitivity to brain tissue was investigated. Results from 1330 separate simulations [(4 lesion volumes × 4 lesion depths for clinical +3 healthy settings) × 7 SDS × 10 simulation = 1330)] each with 100 million photons indicated that selection of SDS is critical to acquire optimal measurements from the brain and recommended SDS to be 25 to 35 mm depending on the wavelengths to obtain optical monitoring of the adult brain function. The findings here can guide the design of future NIRS probes for functional neuroimaging and clinical diagnostic systems.