The apolipoprotein A5 gene-1131 T→C polymorphism affects vitamin E plasma concentrations in type 2 diabetic patients
The apolipoprotein A5 gene-1131 T→C polymorphism affects vitamin E plasma concentrations in type 2 diabetic patients
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DOI：
10.1515/cclm.2008.110
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发表时间：
2008-01-01
影响因子：
6.8
通讯作者：
Masana, Lluis
中科院分区：
文献类型：
--
作者：
Girona, Josefa;Guardiola, Montse;Masana, Lluis
背景：载脂蛋白 A5 (APOA5) 基因的变异与高甘油三酯血症密切相关。维生素 E 在富含甘油三酯 (TG) 的脂蛋白中运输，因此也可以通过 apoAV 进行调节。 2 型糖尿病患者有高 TG 值和氧化应激增加的倾向。方法：我们研究了 169 名非吸烟 2 型糖尿病患者的 APOA5 遗传变异 (-1131 T -> C) 对维生素 E 和氧化状态的影响。分析血浆样本中的脂质、脂蛋白、维生素 E、氧化低密度脂蛋白 (oxLDL)、脂过氧化物、抗 oxLDL 的自身抗体以及 LDL 的二烯形成。结果：与 TT 携带者相比，TC 携带者的维生素 E 浓度较高（45.48 +/- 8.20 mu mol/L vs. 40.32 +/- 10.47 mu mol/L； p=0.02）。在维生素 E 浓度高的个体中，TC 基因型的患病率高出 2.6 倍 (p=0.02)。 APOA5 多态性并未确定氧化状态的任何差异。由于极低密度脂蛋白 (VLDL) 和高密度脂蛋白中的 TG 浓度较高，TC 基因型携带者的空腹 TG 浓度显着高出 21% (p=0.04)。 结论：APOA5-1131 T -> C 多态性与糖尿病患者中较高的维生素 E 浓度和较高的 VLDL-TG 相关。
Background: Variations of the apolipoprotein A5 (APOA5) gene are strongly associated with hypertriglyceridemia. Vitamin E is transported in triglyceride (TG)-rich lipoproteins and therefore could also be modulated by apoAV. Patients with type 2 diabetes have a tendency towards high TG values and increased oxidative stress.Methods: We examined the impact of genetic APOA5 variation (-1131 T -> C) on vitamin E and oxidative status in 169 non-smoker type 2 diabetic patients. Plasma samples were analyzed for lipids, lipoproteins, vitamin E, oxidized low-density lipoprotein (oxLDL), lipoperoxides, autoantibodies against oxLDL and diene formation of LDL.Results: Vitamin E concentrations were higher in TC carriers compared with TT carriers (45.48 +/- 8.20 mu mol/L vs. 40.32 +/- 10.47 mu mol/L; p=0.02). The prevalence of the TC genotype was 2.6-fold higher among individuals with high vitamin E concentrations (p=0.02). The APOA5 polymorphism did not determine any differences in oxidative status. Fasting TG concentration was a significant 21% higher in carriers of the TC genotype (p=0.04) due to higher TG concentrations in very-low-density lipoprotein (VLDL) and high-density lipoprotein.Conclusions: The APOA5-1131 T -> C polymorphism is associated with both higher vitamin E concentrations and higher VLDL-TGs in diabetic patients.