PROTECTIVE IMMUNITY AND EOSINOPHILIA IN IGE-DEFICIENT SJA/9 MICE INFECTED WITH NIPPOSTRONGYLUS-BRASILIENSIS AND TRICHINELLA-SPIRALIS
PROTECTIVE IMMUNITY AND EOSINOPHILIA IN IGE-DEFICIENT SJA/9 MICE INFECTED WITH NIPPOSTRONGYLUS-BRASILIENSIS AND TRICHINELLA-SPIRALIS
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DOI：
10.1073/pnas.85.12.4460
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发表时间：
1988-06-01
影响因子：
11.1
通讯作者：
OVARY, Z
中科院分区：
文献类型：
--
作者：
WATANABE, N;KATAKURA, K;OVARY, Z
为了阐明IgE抗体在宿主对蠕虫感染的反应中的作用，选择性IgE缺陷型SJA/9小鼠感染线虫寄生虫巴西日本圆线虫，其显著增强IgE产生，旋毛虫，其诱导正常小鼠产生强的抗旋毛虫IgE抗体。在两种感染中，SJA/9小鼠的血液嗜酸性粒细胞增多症、原发感染后的蠕虫负荷和对继发感染的抵抗力的动力学与用作产生IgE的对照的同类SJL/J小鼠中的动力学相同。这些结果表明，这里检查的主机响应IgE独立的机制下运作。
To elucidate the roles of IgE antibody in host responses to helminth infection, selective IgE-deficient SJA/9 mice were infected with the nematode parasites Nippostrongylus brasiliensis, which elicits remarkable potentiated IgE production, and Trichinella spiralis, which induces strong anti-Trichinella IgE antibody production in normal mice. The kinetics of blood eosinophilia, worm burden after primary infection, and resistance to secondary infection in SJA/9 mice were the same in both infections as those in congenic SJL/J mice used as an IgE-producing control. These results indicate that the host responses examined here operate under IgE-independent mechanisms.