Big punches come in nanosizes for chemoprevention.
Big punches come in nanosizes for chemoprevention.
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纳米尺寸的大拳头用于化学预防。
DOI：
10.1158/1940-6207.capr-13-0311
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Sukumar,Saraswati
中科院分区：
文献类型：
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作者：
Sharma,Dipali;Sukumar,Saraswati
支持几种生物活性分子的化学预防潜力的文献很多且令人信服，但这些药物的临床开发进展缓慢。开发生物活性化学预防方法的主要障碍包括效力低、缺乏适合口服给药的具有高生物利用度的可靠制剂，以及使用可应用于人类的有意义剂量的相关临床前一级预防模型。本期发表的论文（Grandhi 及其同事）是朝这个方向迈出的重要一步。它显示了口服、低剂量、封装姜黄素和阿司匹林的固体脂质纳米颗粒与游离萝卜硫素相结合，在致癌物诱导的仓鼠模型中对胰腺癌进行长期化学预防的功效。在多种癌症模型中重现这种益处，同时开发中间反应标志物，将使这些发现能够快速转化。它将构成对已知引发和促进致癌作用的关键途径的首次成功的多管齐下攻击。 6（10）； 1007–10。 ©2013 AACR。
Literature to support the chemopreventive potential of several bioactive molecules has been prolific and convincing, but the clinical development of these agents has been slow. Major hurdles for development of bioactive chemoprevention approaches include low potency, lack of reliable formulations with high bioavailability that are suitable for oral administration, and relevant preclinical primary prevention models that use meaningful doses that can be translated to humans. The paper presented in this issue (Grandhi and colleagues) is an important step forward in this direction. It shows the efficacy of an oral, low dose, solid-lipid nanoparticles encapsulated curcumin and aspirin combined with free sulforaphane for long-term chemoprevention of pancreatic cancer in a carcinogen-induced hamster model. Reproducing this benefit in multiple cancer models, accompanied by development of intermediate markers of response will allow rapid translation of these findings. It will constitute the first successful multipronged attack at key pathways known to initiate and promote carcinogenesis.Cancer Prev Res; 6(10); 1007–10. ©2013 AACR.