Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group.
Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group.
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发表时间：
2000
期刊：
影响因子：
9.9
通讯作者：
Antonio Lobo;L. Launer;L. Fratiglioni;K. Andersen;A. Carlo;M. Breteler;J. Copeland;J. Dartigues-J.-Darti
中科院分区：
文献类型：
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作者：
Antonio Lobo;L. Launer;L. Fratiglioni;K. Andersen;A. Carlo;M. Breteler;J. Copeland;J. Dartigues-J.-Darti
欧洲研究中痴呆症患病率数据的最后一次比较是在10年前。作者利用20世纪90年代进行的研究，比较了欧洲65岁及以上人群的痴呆、AD和血管性痴呆（VaD）的年龄和性别特异性患病率。还汇总了这些研究的数据，以获得年龄和性别特异性患病率的稳定估计值。在11个队列中，共确定了2346例轻度至重度痴呆病例。痴呆（所有原因）的标准化患病率为6.4%，AD为4.4%，VaD为1.6%。痴呆症的患病率随着年龄的增长而不断增加，65至69岁组为0.8%，90岁及以上组为28.5%。AD（53.7%病例）的相应数字为0.6%和22.2%，VaD（15.8%病例）为0.3%和5.2%。研究中男性AD患病率的变化最大。在VaD亚型中，观察到研究之间存在很大的差异，男性和女性之间的患病率差异取决于年龄。痴呆症在妇女中更为普遍，AD是患病率随年龄急剧增加的主要原因。
The last comparison of prevalence figures of dementia across European studies was 10 years ago. Using studies conducted in the 1990s, the authors compare the age- and sex-specific prevalence of dementia, AD, and vascular dementia (VaD) across European population-based studies of persons 65 years and older. Data from these studies were also pooled to obtain stable estimates of age- and sex-specific prevalence. A total of 2346 cases of mild to severe dementia were identified in 11 cohorts. Age-standardized prevalence was 6.4% for dementia (all causes), 4.4% for AD, and 1.6% for VaD. The prevalence of dementia increased continuously with age and was 0.8% in the group age 65 to 69 years and 28.5% at age 90 years and older. The corresponding figures for AD (53.7% of cases) were 0.6% and 22.2%, and for VaD (15.8% of cases), 0.3% and 5.2%. Variation of AD prevalence across studies was greatest for men. In the VaD subtype, a large variation across studies was observed, as well as a difference in prevalence between men and women that was age dependent. Dementia is more prevalent in women, and AD is the main contributor to the steep increase of prevalence with age.