IgG subclass-restricted immune responses to allergens.
IgG subclass-restricted immune responses to allergens.
复制标题
对过敏原的 IgG 亚类限制性免疫反应。
DOI：
10.1007/bf00225325
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Lucas,AH
中科院分区：
文献类型：
--
作者：
Lucas,AH
The IgG responses to a variety of allergens are predominated by IgG1 and IgG4 antibodies. With several allergens, the IgG1 response appears to precede the IgG4 response and this switch may be driven by repeated allergen exposure. It remains to be determined whether there is any causal relationship between subclass restriction and the regulation of specific IgE. The question of whether IgG4 antibodies are protective or pathological is still unresolved. Human models are needed to further analyze the interrelationships between T cells, cytokines and B cell isotype expression. The antibody response to allergens appears to be an ideal experimental system for studying antigen-specific isotype regulation in humans. The subclass patterns are remarkably reproducible between individuals, and allergic and normal human subjects, who have been immunized naturally or therapeutically, are readily available as a source of cells. Isolation of allergen-specific T cells that putatively regulate subclass expression would seem to be a worthwile endeavor. Understanding the molecular and cellular events that initiate and control isotype expression will play an important role in the rational design of immunogens and therapeutics, aimed at optimizing protective immunity and diminishing the pathological effects of autoimmune and allergic responses.
