Making sense of IL-6 signalling cues in pathophysiology.
Making sense of IL-6 signalling cues in pathophysiology.
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DOI：
10.1002/1873-3468.14201
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发表时间：
2022-03
期刊：
影响因子：
3.5
通讯作者：
Jones, Simon A.
中科院分区：
文献类型：
--
作者：
Millrine, David;Jenkins, Robert H.;Hughes, Stuart T. O.;Jones, Simon A.
关键词：
解释功能多效性的分子机制是细胞因子生物学研究人员面临的主要挑战。细胞因子-受体交叉反应性和共享信号传导途径被认为是细胞因子多效性的主要驱动因素。然而，通过Jak‐STAT细胞因子信号传导研究总结的报告确定了转录因子调控的有趣的生化和表观遗传决定因素，这些决定因素影响信号依赖性细胞因子应答的传递。在这里，STAT转录因子之间的调节相互作用及其与特定基因组增强子的会聚支持细胞因子反应的微调，控制宿主免疫、功能特性以及组织稳态和修复。在这篇综述中，我们提供了一个概述的信号网络，塑造细胞的感觉和解释细胞因子的线索。通过强调白细胞介素-6的生物学，我们强调了这些机制对生理过程和病理生理结果的重要性。白细胞介素-6信号传导盒控制对稳态、免疫防御和疾病进展至关重要的细胞因子活性。在这篇综述中，我们讨论了确定IL-6生物活性和生物利用度的调控过程。我们考虑了协调和微调Jak-STAT信号传递的细胞内事件，并探索了在生理学和病理生理学中决定IL-6信号解释的转录机制。
Unravelling the molecular mechanisms that account for functional pleiotropy is a major challenge for researchers in cytokine biology. Cytokine–receptor cross‐reactivity and shared signalling pathways are considered primary drivers of cytokine pleiotropy. However, reports epitomized by studies of Jak‐STAT cytokine signalling identify interesting biochemical and epigenetic determinants of transcription factor regulation that affect the delivery of signal‐dependent cytokine responses. Here, a regulatory interplay between STAT transcription factors and their convergence to specific genomic enhancers support the fine‐tuning of cytokine responses controlling host immunity, functional identity, and tissue homeostasis and repair. In this review, we provide an overview of the signalling networks that shape the way cells sense and interpret cytokine cues. With an emphasis on the biology of interleukin‐6, we highlight the importance of these mechanisms to both physiological processes and pathophysiological outcomes. The interleukin‐6 signalling cassette controls cytokine activities essential for homeostasis, immune defence and disease progression. In this review, we discuss the regulatory processes determining IL‐6 bioactivity and bioavailability. We consider the intracellular events that orchestrate and fine‐tune the delivery of Jak‐STAT signals and explore the transcriptional mechanisms that dictate the interpretation of IL‐6 signals in physiology and pathophysiology.
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影响因子：
3.7
作者：
Collins AS;McCoy CE;Lloyd AT;O'Farrelly C;Stevenson NJ
通讯作者：
Stevenson NJ
影响因子：
--
作者：
Albani, Diego;Batelli, Sara;Forloni, Gianluigi
通讯作者：
Forloni, Gianluigi
DOI：
10.4161/jkst.20045
发表时间：
2012-04-01
期刊：
JAK-STAT
影响因子：
--
作者：
Avalle L;Pensa S;Regis G;Novelli F;Poli V
通讯作者：
Poli V
影响因子：
30.8
作者：
Deloukas, Panos;Kanoni, Stavroula;Willenborg, Christina;Farrall, Martin;Assimes, Themistocles L.;Thompson, John R.;Ingelsson, Erik;Saleheen, Danish;Erdmann, Jeanette;Goldstein, Benjamin A.;Stirrups, Kathleen;Koenig, Inke R.;Cazier, Jean-Baptiste;Johansson, Asa;Hall, Alistair S.;Lee, Jong-Young;Willer, Cristen J.;Chambers, John C.;Esko, Tonu;Folkersen, Lasse;Goel, Anuj;Grundberg, Elin;Havulinna, Aki S.;Ho, Weang K.;Hopewell, Jemma C.;Eriksson, Niclas;Kleber, Marcus E.;Kristiansson, Kati;Lundmark, Per;Lyytikainen, Leo-Pekka;Rafelt, Suzanne;Shungin, Dmitry;Strawbridge, Rona J.;Thorleifsson, Gudmar;Tikkanen, Emmi;Van Zuydam, Natalie;Voight, Benjamin F.;Waite, Lindsay L.;Zhang, Weihua;Ziegler, Andreas;Absher, Devin;Altshuler, David;Balmforth, Anthony J.;Barroso, Ines;Braund, Peter S.;Burgdorf, Christof;Claudi-Boehm, Simone;Cox, David;Dimitriou, Maria;Do, Ron;Doney, Alex S. F.;El Mokhtari, NourEddine;Eriksson, Per;Fischer, Krista;Fontanillas, Pierre;Franco-Cereceda, Anders;Gigante, Bruna;Groop, Leif;Gustafsson, Stefan;Hager, Joerg;Hallmans, Goran;Han, Bok-Ghee;Hunt, Sarah E.;Kang, Hyun M.;Illig, Thomas;Kessler, Thorsten;Knowles, Joshua W.;Kolovou, Genovefa;Kuusisto, Johanna;Langenberg, Claudia;Langford, Cordelia;Leander, Karin;Lokki, Marja-Liisa;Lundmark, Anders;McCarthy, Mark I.;Meisinger, Christa;Melander, Olle;Mihailov, Evelin;Maouche, Seraya;Morris, Andrew D.;Mueller-Nurasyid, Martina;Nikus, Kjell;Peden, John F.;Rayner, N. William;Rasheed, Asif;Rosinger, Silke;Rubin, Diana;Rumpf, Moritz P.;Schaefer, Arne;Sivananthan, Mohan;Song, Ci;Stewart, Alexandre F. R.;Tan, Sian-Tsung;Thorgeirsson, Gudmundur;van der Schoot, C. Ellen;Wagner, Peter J.;Wells, George A.;Wild, Philipp S.;Yang, Tsun-Po;Amouyel, Philippe;Arveiler, Dominique;Basart, Hanneke;Boehnke, Michael;Boerwinkle, Eric;Brambilla, Paolo;Cambien, Francois;Cupples, Adrienne L.;de Faire, Ulf;Dehghan, Abbas;Diemert, Patrick;Epstein, Stephen E.;Evans, Alun;Ferrario, Marco M.;Ferrieres, Jean;Gauguier, Dominique;Go, Alan S.;Goodall, Alison H.;Gudnason, Villi;Hazen, Stanley L.;Holm, Hilma;Iribarren, Carlos;Jang, Yangsoo;Kahonen, Mika;Kee, Frank;Kim, Hyo-Soo;Klopp, Norman;Koenig, Wolfgang;Kratzer, Wolfgang;Kuulasmaa, Kari;Laakso, Markku;Laaksonen, Reijo;Lee, Ji-Young;Lind, Lars;Ouwehand, Willem H.;Parish, Sarah;Park, Jeong E.;Pedersen, Nancy L.;Peters, Annette;Quertermous, Thomas;Rader, Daniel J.;Salomaa, Veikko;Schadt, Eric;Shah, Svati H.;Sinisalo, Juha;Stark, Klaus;Stefansson, Kari;Tregouet, David-Alexandre;Virtamo, Jarmo;Wallentin, Lars;Wareham, Nicholas;Zimmermann, Martina E.;Nieminen, Markku S.;Hengstenberg, Christian;Sandhu, Manjinder S.;Pastinen, Tomi;Syvanen, Ann-Christine;Hovingh, G. Kees;Dedoussis, George;Franks, Paul W.;Lehtimaki, Terho;Metspalu, Andres;Zalloua, Pierre A.;Siegbahn, Agneta;Schreiber, Stefan;Ripatti, Samuli;Blankenberg, Stefan S.;Perola, Markus;Clarke, Robert;Boehm, Bernhard O.;O'Donnell, Christopher;Reilly, Muredach P.;Maerz, Winfried;Collins, Rory;Kathiresan, Sekar;Hamsten, Anders;Kooner, Jaspal S.;Thorsteinsdottir, Unnur;Danesh, John;Palmer, Colin N. A.;Roberts, Robert;Watkins, Hugh;Schunkert, Heribert;Samani, Nilesh J.
通讯作者：
Samani, Nilesh J.
影响因子：
4.8
作者：
Chehboun, Salma;Labrecque-Carbonneau, Jeremie;Gauchat, Jean-Francois
通讯作者：
Gauchat, Jean-Francois