THE EPIDEMIOLOGY OF LUNG-CANCER IN XUAN-WEI, CHINA - CURRENT PROGRESS, ISSUES, AND RESEARCH STRATEGIES
THE EPIDEMIOLOGY OF LUNG-CANCER IN XUAN-WEI, CHINA - CURRENT PROGRESS, ISSUES, AND RESEARCH STRATEGIES
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DOI：
10.1080/00039896.1988.9935850
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发表时间：
1988-03-01
期刊：
影响因子：
--
通讯作者：
YANG, RD
中科院分区：
文献类型：
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作者：
CHAPMAN, RS;MUMFORD, JL;YANG, RD
宣威是中国一个约有100万人口的农村县，女性肺癌年死亡率是中国最高的，男性也是中国最高的。宣威的室内空气污染水平非常高（有时超过20毫克/立方米），居民稳定的人口，相对简单的生活方式，以及肺癌死亡率的广泛地理差异，使其非常适合定量，跨学科的研究化学致癌物由于室内空气污染。迄今为止，流行病学调查结果显示，肺癌与室内燃烧“冒烟”煤（而不是“无烟”煤或木材）的关系比与吸烟或职业的关系更密切。目前的空气动力学、化学和毒理学研究结果倾向于证实这种联系，尽管宣威室内空气污染的具体致癌成分尚未确定。中国和美国的研究人员正在进行跨学科的现场和实验室调查，以量化与其他因素相关的室内空气污染的肺癌风险，测量和比较不同宣威燃料的污染特征，确定污染成分和浓度的相对病因学重要性，并建立空气污染剂量与肺癌风险之间的定量关系。
In Xuan Wei, a rural Chinese county of about one million people, females' annual lung cancer mortality is China's highest, and males' is among China's highest. Xuan Wei's very high indoor air pollution levels (sometimes exceeding 20 mg/m3), residentially stable population, relatively uncomplicated lifestyle, and wide geographic variation in lung cancer mortality render it highly amenable to quantitative, interdisciplinary investigation of chemical carcinogens due to indoor air pollution. To date, epidemiologic findings reveal a closer association of lung cancer with the indoor burning of “smoky” coal (as opposed to “smokeless” coal or wood) than with tobacco use or occupation. Current aerometric, chemical, and toxicologic findings tend to confirm this association, though the specific carcinogenic constituents of Xuan Wei indoor air pollution have not yet been determined. Chinese and American investigators are conducting interdisciplinary field and laboratory investigations to quantify the lung cancer risk attendant on indoor air pollution relative to other factors, to measure and compare the characteristics of pollution from different Xuan Wei fuels, to determine the relative etiologic importance of pollution composition and concentration, and to develop quantitative relationships between air pollution dose and lung cancer risk.