Droplet position control in digital microfluidic systems
Droplet position control in digital microfluidic systems
复制标题
DOI：
10.1007/s10544-009-9366-9
复制
发表时间：
2010-02-01
影响因子：
2.8
通讯作者：
Najjaran, Homayoun
中科院分区：
文献类型：
--
作者：
Bhattacharjee, Biddut;Najjaran, Homayoun
在过去的几年中，能够操纵基于细胞的结构上的单个微滴的所谓数字微流体系统（DMS）的研究已经大大增加，主要是由于技术依赖的生物医学应用的需求。这一领域的重要研究涉及液滴运动的模拟和建模、在实验室规模的原型上演示不同的液滴致动技术以及用于更有效的测定程序的液滴路由和调度。本文介绍了DMS的控制分析和设计的基础知识，这是一个相对未开发的数字微流体领域。本文首先讨论了一个简化的动态模型的液滴运动在一个平面阵列的细胞，并继续与更复杂的动态模型，是必要的实现一个适当的闭环控制系统的DMS的结构。控制分析和设计包括DMS在外部驱动力下的瞬态和稳态响应。所提出的控制分析和设计方法被实施到SIMULINK（R）模型中，以通过使用文献中先前报道的系统参数的仿真来证明DMS的性能。
Research on so called digital microfluidic systems (DMS) capable of manipulating individual micro-droplets on a cell-based structure has enormously increased in the past few years, mainly due to the demand of the technology-dependent biomedical applications. Significant research in this area has been related to the simulation and modeling of droplet motion, demonstration of different drop actuation techniques on laboratory-scale prototypes, and droplet routing and scheduling for more efficient assay procedures. This paper introduces the basics of the control analysis and design of a DMS, which is a relatively unexplored area in digital microfluidics. This paper starts with a discussion on a simplified dynamic model of droplet motion in a planar array of cells, and continues with more complicated dynamic models that are necessary to realize the structure of an appropriate closed-loop control system for the DMS. The control analysis and design includes both the transient and steady-state responses of the DMS under external driving forces. The proposed control analysis and design approach is implemented into SIMULINK (R) models to demonstrate the performance of the DMS through simulation using the system parameters previously reported in the literature.