Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin.
Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin.
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DOI：
10.1016/j.ajog.2010.01.035
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发表时间：
2010-04
影响因子：
9.8
通讯作者：
Ahmed MS
中科院分区：
文献类型：
--
作者：
Hemauer SJ;Patrikeeva SL;Nanovskaya TN;Hankins GD;Ahmed MS
胎盘外排转运蛋白的底物可以竞争单个转运蛋白，这可能导致每种底物向胎儿循环的转移增加。我们的目的是确定胎盘转运蛋白在口服降糖药物生物处置中的作用，这些药物可用于妊娠期糖尿病的单药治疗或联合治疗。使用足月胎盘的由内而外刷状缘膜囊泡，通过P-gp、乳腺癌耐药蛋白（BCRP）和多药耐药蛋白（MRP 1）测定格列本脲、罗格列酮和二甲双胍的外排。格列本脲通过MRP 1（43 ± 4%）、BCRP（25 ± 5%）和P-gp（9 ± 5%）转运。罗格列酮主要通过P-gp转运（71 ± 26%）。甲硫氨酸通过P-gp（58 ± 20%）和BCRP（25 ± 14%）转运。多种胎盘转运蛋白促进格列本脲、罗格列酮和二甲双胍的外排。联合给药可能导致其竞争外排转运蛋白。
Substrates of placental efflux transporters could compete for a single transporter, which could result in an increase in the transfer of each substrate to the fetal circulation. Our aim was to determine the role of placental transporters in the biodisposition of oral hypoglycemic drugs that could be used as monotherapy or in combination therapy for gestational diabetes. Inside-out brush border membrane vesicles from term placentas were used to determine the efflux of glyburide, rosiglitazone, and metformin by P-gp, Breast Cancer Resistance Protein (BCRP), and Multidrug Resistance Protein (MRP1). Glyburide was transported by MRP1 (43 ± 4%); BCRP (25 ± 5%); and P-gp (9 ± 5%). Rosiglitazone was transported predominantly by P-gp (71 ± 26%). Metformin was transported by P-gp (58 ± 20%) and BCRP (25 ± 14%). Multiple placental transporters contribute to efflux of glyburide, rosiglitazone, and metformin. Administration of drug combinations could lead to their competition for efflux transporters.
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影响因子：
5.8
作者：
Hemauer, Sarah J.;Nanovskaya, Tatiana N.;Abdel-Rahman, Sherif Z.;Patrikeeva, Svetlana L.;Hankins, Gary D. V.;Ahmed, Mahmoud S.
通讯作者：
Ahmed, Mahmoud S.
影响因子：
5.9
作者：
Dailey, GE;Noor, MA;Fiedorek, FT
通讯作者：
Fiedorek, FT
影响因子：
9.8
作者：
Holmes, Heather J.;Casey, Brian M.;Bawdon, Roger E.
通讯作者：
Bawdon, Roger E.
影响因子：
9.8
作者：
Kraemer, Jennifer;Klein, Julia;Koren, Gideon
通讯作者：
Koren, Gideon
DOI：
10.1152/ajpregu.2000.279.4.r1495
发表时间：
2000-10-01
影响因子：
2.8
作者：
St-Pierre, MV;Serrano, MA;Marin, JJG
通讯作者：
Marin, JJG