Genomic history of the seventh pandemic of cholera in Africa
Genomic history of the seventh pandemic of cholera in Africa
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DOI：
10.1126/science.aad5901
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发表时间：
2017-11-10
期刊：
影响因子：
56.9
通讯作者：
Thomson, Nicholas R.
中科院分区：
文献类型：
--
作者：
Weill, Francois-Xavier;Domman, Daryl;Thomson, Nicholas R.
第七次霍乱大流行严重影响了非洲，尽管该疾病的起源和在大陆的传播仍不清楚。我们使用了来自45个非洲国家、49年间1070株01型霍乱弧菌分离株的基因组数据，以表明过去的流行病可归因于单一的扩大谱系。自1970年以来，这一谱系被引入西非和东非/南部非洲两个主要地区至少11次，造成持续长达28年的流行病。最近5次从亚洲传入非洲的病毒都是耐多药亚型，在2000年后取代了抗生素敏感亚型。这一系统发育框架描述了霍乱谱系引入的周期性和霍乱传播的稳定途径，可为合理设计非洲霍乱控制措施提供信息。
The seventh cholera pandemic has heavily affected Africa, although the origin and continental spread of the disease remain undefined. We used genomic data from 1070 Vibrio cholerae O1 isolates, across 45 African countries and over a 49-year period, to show that past epidemics were attributable to a single expanded lineage. This lineage was introduced at least 11 times since 1970, into two main regions, West Africa and East/ Southern Africa, causing epidemics that lasted up to 28 years. The last five introductions into Africa, all from Asia, involved multidrug-resistant sublineages that replaced antibiotic-susceptible sublineages after 2000. This phylogenetic framework describes the periodicity of lineage introduction and the stable routes of cholera spread, which should inform the rational design of control measures for cholera in Africa.