Changes in salivary physiological stress markers induced by muscle stretching in patients with irritable bowel syndrome.
Changes in salivary physiological stress markers induced by muscle stretching in patients with irritable bowel syndrome.
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DOI：
10.1186/1751-0759-2-20
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发表时间：
2008-11-04
影响因子：
2.1
通讯作者：
Sakurai, Kohji
中科院分区：
文献类型：
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作者：
Hamaguchi, Toyohiro;Fukudo, Shin;Kanazawa, Motoyori;Tomiie, Tadaaki;Shimizu, Kunihiko;Oyama, Mineo;Sakurai, Kohji
心理生理过程在肠易激综合征（IBS）中起着重要作用，但肌肉拉伸对应激标志物嗜铬粒蛋白A（CgA）的调节作用尚未见报道。我们假设，腹部肌肉拉伸作为一种被动的操作将有一个有益的影响的交感神经/肾上腺髓质系统（唾液CGA）和焦虑的活动的生化指标。15个对照组和18个未治疗的IBS受试者进行实验性腹部肌肉拉伸4分钟。受试者在仰卧位放松，他们的膝盖完全弯曲，而他们的骨盆和躯干旋转被动和缓慢地从0度的腹部旋转到约90度或受试者报告感觉不适的点。比较两组受试者拉伸前后胃肠道症状评定量表（GSRS）、状态特质焦虑量表（STAI）、抑郁自评量表（SDS）、纵坐标量表和唾液CgA水平的变化。对唾液CgA进行三因素方差分析（ANOVA），其中时期（之前与之后）作为受试者内因素，组（IBS与对照组）和性别（男性与女性）作为受试者间因素。CgA显示阶段与组之间（F[1，31] = 4.89，p = 0.03）以及组与性别之间（F[1，31] = 4.73，p = 0.03）存在显著相互作用。未显示CgA分泌的时期和性别之间的相互作用（F[1，3] = 2.60，p = 0.12）。在基线时，IBS受试者的唾液CgA（36.7 ± 5.9 pmol/mg）显著高于对照组（19.9 ± 5.5 pmol/mg，p < 0.05）。在拉伸后，IBS组的唾液CgA显著降低（25.5 ± 4.5 pmol/mg），该值与对照组（18.6 ± 3.9 pmol/mg）无差异。我们的研究结果表明，改善IBS的病理生理的可能性，由CGA，交感神经/肾上腺髓质系统的活动的生化指标所示的被动腹肌拉伸。
Psychophysiological processing has been reported to play a crucial role in irritable bowel syndrome (IBS) but there has been no report on modulation of the stress marker chromogranin A (CgA) resulting from muscle stretching. We hypothesized that abdominal muscle stretching as a passive operation would have a beneficial effect on a biochemical index of the activity of the sympathetic/adrenomedullary system (salivary CgA) and anxiety. Fifteen control and eighteen untreated IBS subjects underwent experimental abdominal muscle stretching for 4 min. Subjects relaxed in a supine position with their knees fully flexed while their pelvic and trunk rotation was passively and slowly moved from 0 degrees of abdominal rotation to about 90 degrees or the point where the subject reported feeling discomfort. Changes in the Gastrointestinal Symptoms Rating Scale (GSRS), State Trait Anxiety Inventory (STAI), Self-rating Depression Scale (SDS), ordinate scale and salivary CgA levels were compared between controls and IBS subjects before and after stretching. A three-factor analysis of variance (ANOVA) with period (before vs. after) as the within-subject factor and group (IBS vs. Control), and sex (men vs. female) as the between-subject factors was carried out on salivary CgA. CgA showed significant interactions between period and groups (F[1, 31] = 4.89, p = 0.03), and between groups and sex (F[1, 31] = 4.73, p = 0.03). Interactions between period and sex of CgA secretion were not shown (F[1, 3] = 2.60, p = 0.12). At the baseline, salivary CgA in IBS subjects (36.7 ± 5.9 pmol/mg) was significantly higher than in controls (19.9 ± 5.5 pmol/mg, p < 0.05). After the stretching, salivary CgA significantly decreased in the IBS group (25.5 ± 4.5 pmol/mg), and this value did not differ from that in controls (18.6 ± 3.9 pmol/mg). Our results suggest the possibility of improving IBS pathophysiology by passive abdominal muscle stretching as indicated by CgA, a biochemical index of the activity of the sympathetic/adrenomedullary system.