INHIBITION OF THE COMPLEMENT CASCADE BY THE MAJOR SECRETORY PROTEIN OF VACCINIA VIRUS
INHIBITION OF THE COMPLEMENT CASCADE BY THE MAJOR SECRETORY PROTEIN OF VACCINIA VIRUS
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DOI：
10.1126/science.2237434
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发表时间：
1990-11-09
期刊：
影响因子：
56.9
通讯作者：
MOSS, B
中科院分区：
文献类型：
--
作者：
KOTWAL, GJ;ISAACS, SN;MOSS, B
补体系统有助于宿主防御感染性病原体的入侵。一种35千道尔顿的蛋白质，由痘苗病毒编码，由感染细胞分泌，与包括补体控制蛋白在内的基因家族成员具有序列相似性。生化和遗传学研究表明，病毒蛋白与补体第四组分的衍生物结合，并抑制经典的补体级联反应，这表明它作为一种防御分子，帮助病毒逃避补体激活的后果。
The complement system contributes to host defenses against invasion by infectious agents. A 35-kilodalton protein, encoded by vaccinia virus and secreted from infected cells, has sequence similarities to members of a gene family that includes complement control proteins. Biochemical and genetic studies showed that the viral protein binds to derivatives of the fourth component of complement and inhibits the classical complement cascade, suggesting that it serves as a defense molecule to help the virus evade the consequences of complement activation.