Defining preterm delivery - the epidemiology of clinical presentation
Defining preterm delivery - the epidemiology of clinical presentation
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DOI：
10.1046/j.1365-3016.2000.00293.x
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发表时间：
2000-10-01
影响因子：
2.8
通讯作者：
Selvin, S
中科院分区：
文献类型：
--
作者：
Pickett, KE;Abrams, B;Selvin, S
早产有可能不是一个单一的实体，而是一系列具有不同病因的疾病，最终导致婴儿在怀孕37周之前出生。虽然一些研究人员报告了病因学上的异质性，但其他研究人员没有发现亚型之间的差异，或者对将早产分为亚型的可取性和有效性提出了争议。这项研究探讨了1980年至1990年在加州大学旧金山分校莫菲特医院分娩的7000多名黑人和白人妇女的母亲风险因素与早产类型的关系。尽管个别风险因素的影响程度因早产亚型不同而不同，但与两类自发早产显著相关的风险因素集是相同的，而与医学上表明的早产相关的风险因素集是不同的。这项研究表明，虽然自然早产和医学上表明的早产之间的区别似乎是正确的，但区分自然早产的类型可能不会导致有用的病因学推断。
It is possible that preterm delivery is not a single entity but a cluster of conditions with different aetiologies that ultimately result in the delivery of an infant before 37 completed weeks of gestation. Whereas some researchers have reported aetiological heterogeneity, others have found no differences between subtypes or have disputed the desirability and utility of classifying preterm birth into subtypes. This study explores the relationship of maternal risk factors to type of preterm delivery in a cohort of over 7000 black and white women delivering singleton infants at the University of California, San Francisco's Moffitt Hospital between 1980 and 1990. Although the magnitude of the effect of individual risk factors differed between preterm delivery subtypes, the set of risk factors significantly associated with both categories of spontaneous preterm delivery was identical, while that associated with medically indicated preterm births was different. This study indicates that whereas the distinction between spontaneous preterm deliveries and those that are medically indicated seems valid, distinguishing between types of spontaneous preterm births may not lead to useful aetiological inferences.