Iridium-catalyzed enantioselective allylic substitutions with aliphatic nitro compounds as prenucleophiles
Iridium-catalyzed enantioselective allylic substitutions with aliphatic nitro compounds as prenucleophiles
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DOI：
10.1055/s-2006-933121
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发表时间：
2006-03-17
期刊：
影响因子：
2
通讯作者：
Helmchen, G
中科院分区：
文献类型：
--
作者：
Dahnz, A;Helmchen, G
报道了以硝酸烷和硝酸乙酸乙酯为亲核试剂的对映选择性烯丙基烷基化反应。用磷酰胺和[Ir(COD)Cl](2)的混合物原位活化制备的催化剂，ee可达99%。该方法应用于抗抑郁药(1S,2R)-反式-2-苯基环戊胺的合成。
Enantioselective Ir-catalyzed allylic alkylations with nitroalkanes and ethyl nitroacetate as nucleophiles are reported. Up to 99% ee was achieved using catalysts prepared by in situ activation of mixtures of phosphorus amidites and [Ir(COD)Cl](2). The method was applied to a synthesis of the antidepressant (1S,2R)-trans-2-phenylcyclopentanamine.