The presentation of a hepatitis C viral peptide by distinct major histocompatibility complex class I allotypes from two chimpanzee species.
The presentation of a hepatitis C viral peptide by distinct major histocompatibility complex class I allotypes from two chimpanzee species.
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来自两种黑猩猩物种的不同主要组织相容性复合体 I 类同种异型呈现丙型肝炎病毒肽。
DOI：
10.1084/jem.183.2.663
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Parham,P
中科院分区：
文献类型：
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作者：
Cooper,S;Kowalski,H;Erickson,AL;Arnett,K;Little,AM;Walker,CM;Parham,P
来自患有丙型肝炎的普通黑猩猩（Pan troglodytes）肝脏的细胞毒性T淋巴细胞（CTL）系特异性识别由主要组织相容性复合体（MHC）I类分子Patr-A04结合的丙型肝炎病毒9-mer肽（单字母氨基酸代码中的KHP-DATYSR）。该相同的CTL系还识别由结构上不同的I类分子Papa-A06结合的相同肽，Papa-A06来源于不同的黑猩猩物种，Pan paniscus或pygmy黑猩猩。这些I类同种异型相差6个氨基酸，但尽管结构不同，但具有相同的抗原呈递功能。这是第一次观察到抗原呈递给一个给定的T细胞受体的不同的MHC I类同种异型从不同的物种。
A cytotoxic T lymphocyte (CTL) line, derived from the liver of a common chimpanzee (Pan troglodytes) with hepatitis C, specifically recognized a hepatitis C viral 9-mer peptide (KHP-DATYSR in single-letter amino acid code) bound by the major histocompatibility complex (MHC) class I molecule, Patr-A04. This same CTL line also recognized the identical peptide bound by a structurally different class I molecule, Papa-A06, derived from the separate chimpanzee species, Pan paniscus or pygmy chimpanzee. These class I allotypes differ by six amino acids but, in spite of the structural differences, share the same antigen-presenting function. This is the first observation of antigen presentation to a given T cell receptor by different MHC class I allotypes from separate species.