A conserved module regulates receptor kinase signalling in immunity and development
A conserved module regulates receptor kinase signalling in immunity and development
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DOI：
10.1038/s41477-022-01134-w
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发表时间：
2022-04-14
期刊：
影响因子：
18
通讯作者：
Nimchuk, Zachary L.
中科院分区：
文献类型：
--
作者：
DeFalco, Thomas A.;Anne, Pauline;Nimchuk, Zachary L.
细胞表面受体对配体的识别是动物和植物发育和免疫的基础。调节受体信号传导对于适当的细胞反应至关重要，但确保这一点的机制知之甚少。在这里，我们表明，植物受体的病原体相关的分子模式（PAMPs）在免疫和CLAVATA 3/胚胎周围区域相关肽（CLEp）在发展中使用类似的调节模块的信号。在缺乏配体的情况下，信号传导通过与特定的2C型蛋白磷酸酶结合而减弱。激活后，PAMP和CLEp受体磷酸化趋异胞质激酶，其反过来磷酸化磷酸酶，从而促进受体信号传导。我们的工作揭示了免疫和发育受体信号传导之间共享的调节回路，这可能对植物受体激酶介导的信号传导具有更广泛的重要意义。在这里，作者表明，由RLCK激酶和PP 2C磷酸酶组成的共同机制调节免疫和发育中受体下游的信号传导。
Ligand recognition by cell-surface receptors underlies development and immunity in both animals and plants. Modulating receptor signalling is critical for appropriate cellular responses but the mechanisms ensuring this are poorly understood. Here, we show that signalling by plant receptors for pathogen-associated molecular patterns (PAMPs) in immunity and CLAVATA3/EMBRYO SURROUNDING REGION-RELATED peptides (CLEp) in development uses a similar regulatory module. In the absence of ligand, signalling is dampened through association with specific type-2C protein phosphatases. Upon activation, PAMP and CLEp receptors phosphorylate divergent cytosolic kinases, which, in turn, phosphorylate the phosphatases, thereby promoting receptor signalling. Our work reveals a regulatory circuit shared between immune and developmental receptor signalling, which may have broader important implications for plant receptor kinase-mediated signalling in general.Membrane receptor kinases are involved in many signalling pathways in plants. Here, the authors show that a common mechanism, consisting of a RLCK kinase and a PP2C phosphatase, regulates signalling downstream of receptors, both in immunity and development.