Murine model of chronic human asthma
Murine model of chronic human asthma
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DOI：
10.1046/j.1440-1711.2001.00981.x
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发表时间：
2001-04-01
影响因子：
4
通讯作者：
Foster, PS
中科院分区：
文献类型：
--
作者：
Kumar, RK;Foster, PS
人类哮喘与气道粘膜的急性和慢性炎症相关，伴随着气道壁重塑。小鼠急性过敏性支气管肺炎炎症的实验模型对于研究免疫机制和细胞募集是有用的，但具有显著的局限性，因为它们不能再现人类哮喘的许多特征性病变，同时通常与显著的肺泡炎相关。我们已经开发了一种改进的小鼠哮喘模型，其表现出几乎所有的人类疾病的典型形态和功能变化，而没有任何混淆的肺泡炎。该模型在研究慢性哮喘的发病机制和潜在的治疗方法方面具有相当大的潜力。
Human asthma is associated with acute and chronic inflammation of the airway mucosa, accompanied by airway wall remodelling. Experimental models of acute allergic bronchopulmonary inflammation in mice are useful for investigation of immunological mechanisms and of cellular recruitment, but have significant limitations because they fail to reproduce a number of characteristic lesions of human asthma, while usually being associated with marked alveolitis. We have developed an improved murine model of asthma that exhibits almost all of the morphological and functional changes that typify the human disease, without any confounding alveolitis. This model has considerable potential for the investigation of pathogenetic mechanisms and potential treatments of chronic human asthma.