Combinatorial treatment of photothermal therapy using gold nanoshells with conventional photodynamic therapy to improve treatment efficacy: An in vitro study
Combinatorial treatment of photothermal therapy using gold nanoshells with conventional photodynamic therapy to improve treatment efficacy: An in vitro study
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DOI：
10.1002/lsm.20674
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发表时间：
2008-10-01
影响因子：
2.4
通讯作者：
Olivo, Malini
中科院分区：
文献类型：
--
作者：
Kah, James Chen Yong;Wan, Rachel Cheng Yi;Olivo, Malini
背景和目的：光动力（PDT）和光热（PTT）疗法均已被证明是有效的癌症治疗策略，但将它们组合成单一治疗方式的方法可能会提供更好的治疗效果。我们比较了这种联合治疗与单独治疗的治疗效果。研究设计/材料和方法：我们在选定的体外条件下，以1.44 J/cm(2)的低光剂量进行单独的PDT、PTT和联合治疗，并使用结晶坚牢紫测定法比较它们的细胞活力。结果：与单独的PDT和PTT可将细胞活力分别降低至30.9%和44.0%相比，单次照射下的联合治疗可进一步降低细胞活力。细胞活力达到 17.5%。结论：与传统 PDT 或新兴 PTT 治疗相比，PDT 和 PTT 联合治疗似乎是一种更有效的治疗策略。
Background and Objective: Both photodynamic (PDT) and photothermal (PTT) therapy have proven to be effective treatment strategies for cancer, but the approach of combining them into a single treatment modality may offer better treatment efficacy. We compare the treatment efficacy of such combined treatment with the individual treatment.Study Design/Materials and Methods: We perform the individual PDT, PTT and combined treatment under selected in vitro condition with our low light dose of 1.44 J/cm(2) and compare their cell viability using crystal fast violet assay.Results: Compared to PDT and PTT alone which can reduce cell viability to 30.9% and 44.0% respectively, the combined treatment under a single irradiation can further reduce the cell viability to 17.5%.Conclusion: A combined PDT and PTT treatment appears to be a more effective treatment strategy compared to conventional PDT or emerging PTT treatment.