A free radical approach to functionalization of phosphonates utilizing novel 2- and 3-phosphonyl radicals.
A free radical approach to functionalization of phosphonates utilizing novel 2- and 3-phosphonyl radicals.
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DOI：
10.1016/0040-4020(96)00820-4
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发表时间：
1996-10-21
期刊：
影响因子：
2.1
通讯作者：
Pietrzykowski, WM
中科院分区：
文献类型：
--
作者：
Balczewski, P;Pietrzykowski, WM
本文介绍了在自由基还原条件下膦酰基C-2，C-3-C键形成的一般方法。新的方法是基于合成新的2-和3-膦酰基自由基6，9衍生自相应的2-和3-卤代（X=Cl，Br，I）取代的膦酸酯7，10和它们与烯烃4的反应。以24-73%的产率获得具有2+2和3+2延长碳链的官能化膦酸酯5、8。版权所有（C）1996 Elsevier Science Ltd
A general method for the phosphonyl C-2,C-3-C bond formation under the free radical, reductive conditions is described. The new approach is based on the synthesis of novel 2- and 3- phosphonyl radicals 6, 9 derived from the corresponding 2- and 3-halo (X=Cl, Br, I) substituted phosphonates 7, 10 and their reaction with alkenes 4. Functionalized phosphonates 5, 8 possessing the 2+2 and 3+2 elongated carbon chain were obtained in 24-73% yields. Copyright (C) 1996 Elsevier Science Ltd