Chromosomal imbalances in nasopharyngeal carcinoma: a meta-analysis of comparative genomic hybridization results.
Chromosomal imbalances in nasopharyngeal carcinoma: a meta-analysis of comparative genomic hybridization results.
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DOI：
10.1186/1479-5876-4-4
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发表时间：
2006-01-19
影响因子：
7.4
通讯作者：
Marincola FM
中科院分区：
文献类型：
--
作者：
Li X;Wang E;Zhao YD;Ren JQ;Jin P;Yao KT;Marincola FM
鼻咽癌（NPC）是东南亚地区的一种高发疾病，其患病率明显受遗传背景影响。对于该地理区域的高发病率，人们提出了各种理论，但迄今为止尚未找到结论性的解释。通过比较基因组杂交可识别的染色体失衡可能有助于揭示可能与 NPC 发病和进展相关的常见遗传改变。然而，对文献的回顾显示，报告的结果之间存在矛盾，可能与患者选择、疾病阶段、方法细节差异等相关因素有关。为了提高分析能力并试图找出报告结果之间的共性，我们基于染色体比较基因组杂交（CGH）对鼻咽癌组织中描述的结果进行了荟萃分析。这项荟萃分析揭示了染色体异常的一致模式，这些异常模式似乎在阶段依赖性进展后聚集在基因组的特定“热点”中。
Nasopharyngeal carcinoma (NPC) is a highly prevalent disease in Southeast Asia and its prevalence is clearly affected by genetic background. Various theories have been suggested for its high incidence in this geographical region but to these days no conclusive explanation has been identified. Chromosomal imbalances identifiable through comparative genomic hybridization may shed some light on common genetic alterations that may be of relevance to the onset and progression of NPC. Review of the literature, however, reveals contradictory results among reported findings possibly related to factors associated with patient selection, stage of disease, differences in methodological details etc. To increase the power of the analysis and attempt to identify commonalities among the reported findings, we performed a meta-analysis of results described in NPC tissues based on chromosomal comparative genomic hybridization (CGH). This meta-analysis revealed consistent patters in chromosomal abnormalities that appeared to cluster in specific "hot spots" along the genome following a stage-dependent progression.
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