Changes in Cortical Activation Patterns in Language Areas following an Aerobic Exercise Intervention in Older Adults.
Changes in Cortical Activation Patterns in Language Areas following an Aerobic Exercise Intervention in Older Adults.
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DOI：
10.1155/2017/6340302
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发表时间：
2017
影响因子：
3.1
通讯作者：
McGregor KM
中科院分区：
文献类型：
--
作者：
Nocera J;Crosson B;Mammino K;McGregor KM
先前的研究表明，在语言任务中右额下回（IFG）活动增加的老年人表现出语义语言流畅性的下降。目前的研究试图评估有氧运动干预是否可以改变功能性磁共振成像（fMRI）评估的语义语言流畅性任务期间的大脑活动模式。32名居住在社区、久坐不动的老年人参加了为期12周的有氧“旋转”运动组或为期12周的非有氧运动控制条件（平衡）。30名参与者完成了他们分配的干预（16旋转; 14平衡）与干预前和干预后的语义言语流畅性任务的评估，在功能磁共振成像和估计VO 2 max测试。与平衡组相比，旋转组的最大摄氧量估计值的变化评分显著增加。与评估后的对照组相比，Spin组在扫描仪内的语义语言流畅性输出也有所改善。IFG活动的组fMRI比较显示，与平衡组相比，有氧旋转组干预后右侧IFG的活动较低。影像学数据的回归分析显示，VO 2 max和语义流畅性的变化与右侧IFG的活动呈负相关。目前的工作注册为临床试验，编号为NCT 01787292和NCT 02787655。
Previous work has shown that older adults who evidence increased right inferior frontal gyrus (IFG) activity during language tasks show decreased sematic verbal fluency performance. The current study sought to evaluate if an aerobic exercise intervention can alter patterns of brain activity during a semantic verbal fluency task assessed by functional magnetic resonance imaging (fMRI). Thirty-two community-dwelling, sedentary older adults were enrolled to a 12-week aerobic “Spin” exercise group or a 12-week nonaerobic exercise control condition (Balance). Thirty participants completed their assigned intervention (16 Spin; 14 Balance) with pre- and postintervention assessments of a semantic verbal fluency task during fMRI and estimated VO2max testing. There was a significant increase in the change scores for estimated VO2max of the Spin group when compared to the Balance group. Semantic verbal fluency output within the scanner was also improved in the Spin group as compared to controls at postassessment. Group fMRI comparisons of IFG activity showed lower activity in the right IFG following the intervention in the aerobic Spin group when compared to the Balance group. Regression analysis of imaging data with change in both estimated VO2max and semantic verbal fluency was negatively correlated with activity in right IFG. The current work is registered as clinical trial with NCT01787292 and NCT02787655.