The association between alveolar bone loss and pulmonary function: the VA Dental Longitudinal Study.
The association between alveolar bone loss and pulmonary function: the VA Dental Longitudinal Study.
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DOI：
10.1902/annals.1998.3.1.257
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发表时间：
1998-07-01
期刊：
影响因子：
--
通讯作者：
Garcia, R I
中科院分区：
文献类型：
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作者：
Hayes, C;Sparrow, D;Garcia, R I
口腔疾病对医疗结果的影响还不清楚。这项流行病学调查的目的是检查是否慢性阻塞性肺疾病（COPD）的风险是增加个人与牙周病史的评估放射性牙槽骨丢失（ABL）。受试者选自VA牙科纵向研究，这是一项针对基线时身体健康的男性退伍军人的衰老和健康的长期研究。受试者不是VA患者。1秒用力呼气量（FEV 1）小于预测量65%的受试者被归类为COPD。ABL通过使用Schei尺测量的全口系列根尖周片来评估。以20%的增量测量每个邻间部位的骨丢失，并计算平均全口骨丢失评分。Logistic回归分析用于确定基线骨丢失测量对随后25年随访期内发生COPD风险的独立贡献。协变量包括吸烟、身高、年龄、教育程度和饮酒量。在基线时的1，118名医学上健康的齿状男性中，261名随后发展为COPD。我们发现，基线时的ABL状态是COPD的独立风险因素，骨丢失最差人群（每个中心平均ABL > 20%）中的受试者风险显著更高（OR = 1.8; 95% CI = 1.3，2.5）。该分析的结果表明，ABL增加与COPD风险增加相关
The effect of oral conditions on medical outcomes is not well understood. The purpose of this epidemiological investigation was to examine whether the risk for chronic obstructive pulmonary disease (COPD) is enhanced among individuals with a history of periodontal disease as assessed by radiographic alveolar bone loss (ABL). Subjects were selected from the VA Dental Longitudinal Study, a long-term study of aging and health in male veterans who were medically healthy at baseline. Subjects are not VA patients. Those subjects with a forced expiratory volume in 1 second (FEV1) less than 65% of predicted volume were categorized as having COPD. ABL was assessed by using full-mouth series periapical films measured by a Schei ruler. Bone loss at each interproximal site was measured in 20% increments, and the mean whole-mouth bone loss score was calculated. Logistic regression analysis was used to determine the independent contribution of bone loss measurement at baseline to the subsequent risk of developing COPD over a 25-year follow-up period. Covariates included measures of smoking, height, age, education, and alcohol consumption. Of the 1,118 medically healthy dentate men at baseline, 261 subsequently developed COPD. We found that ABL status at baseline was an independent risk factor for COPD, with subjects in the worst population quintile of bone loss (mean ABL > 20% per site) found to be at significantly higher risk (OR = 1.8; 95% CI = 1.3, 2.5). The results of this analysis indicate that increased ABL is associated with an increased risk for COPD