Development and maturation of natural killer cells.
Development and maturation of natural killer cells.
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DOI：
10.1016/j.coi.2016.01.007
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发表时间：
2016-04
影响因子：
7
通讯作者：
Sun JC
中科院分区：
文献类型：
--
作者：
Geiger TL;Sun JC
自然杀伤 (NK) 细胞是先天性淋巴细胞，由于它们能够快速释放炎性细胞因子并杀死感染或转化的细胞，因此对于宿主抵御病原体和癌症至关重要。自最初发现以来的 40 年间，人们对这一重要细胞谱系如何发育和发挥作用有了很多了解。我们现在知道 NK 细胞是先天淋巴细胞 (ILC) 淋巴细胞家族的创始成员。此外，我们最近发现NK细胞可以具有适应性免疫的特征，例如抗原特异性和长效记忆反应。在这里，我们将回顾目前对驱动 NK 细胞从共同淋巴祖细胞 (CLP) 发育到成熟 NK 细胞，以及从激活的效应细胞到长寿命记忆 NK 细胞发育的分子机制的理解。
Natural killer (NK) cells are innate lymphocytes that are critical for host protection against pathogens and cancer due to their ability to rapidly release inflammatory cytokines and kill infected or transformed cells. In the 40 years since their initial discovery, much has been learned about how this important cellular lineage develops and functions. We now know that NK cells are the founding members of an expanded family of lymphocyte known as innate lymphoid cells (ILC). Furthermore, we have recently discovered that NK cells can possess features of adaptive immunity such as antigen specificity and long-lived memory responses. Here we will review our current understanding of the molecular mechanisms driving development of NK cells from the common lymphoid progenitor (CLP) to mature NK cells, and from activated effectors to long-lived memory NK cells.