Renal Medicine 3 Kidney regeneration
Renal Medicine 3 Kidney regeneration
复制标题
DOI：
10.1016/s0140-6736(10)60237-1
复制
发表时间：
2010-04-10
期刊：
影响因子：
168.9
通讯作者：
Remuzzi, Giuseppe
中科院分区：
文献类型：
--
作者：
Benigni, Ariela;Morigi, Marina;Remuzzi, Giuseppe
肾组织再生能力是鱼类的一个显著特征，但通常不是哺乳动物的。然而，有证据表明，肾脏修复是对动物和人类的侮辱性物质的反应。因此，在过去的几年中，研究已经设计，以澄清肾修复的细胞和分子基础，目的是调查动物和人类肾脏的潜在再生能力。本研究解决了三个主要问题：成年动物肾脏中的终末分化细胞是否具有再生能力;肾脏中是否存在多能祖细胞;以及肾外来源的细胞迁移到肾脏以应对损伤是否有利于或加速肾脏修复。在这篇综述中，我们描述了与肾脏修复和再生相关的细胞和分子途径的证据，并回顾了动物和人类研究的数据，这些研究表明肾脏可能具有再生能力。
Neonephrogenesis, the capacity to regenerate renal tissue, is a distinctive feature of fish but not usually of mammals. However, evidence exists for kidney repair in response to insulting agents for animals and human beings. Studies have therefore been designed in the past few years to clarify the cellular and molecular basis of renal repair, with the aim to investigate the potential regenerative capacity of animal and human kidneys. Three main questions are being addressed by this research: whether terminally differentiated cells in adult animal kidneys have regenerative capacity; whether multipotent progenitor cells exist in kidneys; and whether renal repair can be favoured or accelerated by cells of extrarenal origin migrating to the kidney in response to injury. In this Review, we describe evidence of cellular and molecular pathways related to renal repair and regeneration, and review data from animal and human studies that show that the kidney might have regenerative capacity.