DNA-Decorated Two-Dimensional Crystalline Nanosheets
DNA-Decorated Two-Dimensional Crystalline Nanosheets
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DOI：
10.1021/jacs.7b09283
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发表时间：
2017-12-13
影响因子：
15
通讯作者：
Varghese, Reji
中科院分区：
文献类型：
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作者：
Albert, Shine K.;Sivakumar, Irla;Varghese, Reji
设计和合成表面具有DNA等信息丰富分子超密集阵列的高纵横比2D纳米片极具挑战性。在此，我们报告了一种基于两亲性驱动的自组装的通用策略，用于制作高纵横比的2D片材，其表面用DNA密集装饰。显微镜和X射线分析表明，该片材是结晶的。该片材最独特的特征是DNA定向的表面寻址能力，这是通过序列特异性DNA杂交用金纳米颗粒装饰片材的任一面来证明的。我们的研究结果表明，这种设计策略可以作为一种通用的方法，用于合成DNA装饰的高纵横比片，这可能会发现潜在的应用在材料科学，药物输送，和纳米电子学。
Design and synthesis of high aspect ratio 2D nanosheets with surface having ultradense array of information-rich molecule such as DNA is extremely challenging. Herein, we report a universal strategy based on amphiphilicity-driven self-assembly for the crafting of high aspect ratio, 2D sheets that are densely surface decorated with DNA. Microscopy and X-ray analyses have shown that the sheets are crystalline. The most unique feature of the sheets is DNA-directed surface address ability, which is demonstrated through the decoration of either faces of the sheet with gold nanoparticles through sequence-specific DNA hybridization. Our results suggest that this design strategy can be applied as a general approach for the synthesis of DNA decorated high aspect ratio sheets, which may find potential applications in materials science, drug delivery, and nanoelectronics.