A role for fucoseα(1-2)galactose carbohydrates in neuronal growth
A role for fucoseα(1-2)galactose carbohydrates in neuronal growth
复制标题
DOI：
10.1021/ja044631v
复制
发表时间：
2005-02-09
影响因子：
15
通讯作者：
Hsieh-Wilson, LC
中科院分区：
文献类型：
--
作者：
Kalovidouris, SA;Gama, CI;Hsieh-Wilson, LC
We report a fucose α(1−2) galactose-mediated pathway for the modulation of neuronal growth and morphology. Our studies provide strong evidence for the presence of Fucα(1−2)Gal glycoproteins and lectin receptors in hippocampal neurons. Additionally, we show that manipulation of Fucα(1−2)Gal-associated proteins using small-molecule and lectin probes induces dramatic changes in neuronal morphology. These findings may provide a novel pathway to stimulate neuronal growth and regeneration.
