Physiological tracer distribution and benign lesion incidental uptake of Al18F-NOTA-FAPI-04 on PET/CT imaging
Physiological tracer distribution and benign lesion incidental uptake of Al18F-NOTA-FAPI-04 on PET/CT imaging
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DOI：
10.1097/mnm.0000000000001563
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发表时间：
2022-07-01
影响因子：
1.5
通讯作者：
Cheng, Zhuzhong
中科院分区：
文献类型：
--
作者：
Kou, Ying;Jiang, Xuemei;Cheng, Zhuzhong
目的 系统研究(AlF)-F-18-NOTA-FAPI-04（F-18-FAPI）在肿瘤患者体内的生理分布和良性病变偶发摄取情况，建立相关器官和病灶的正常摄取范围。方法对20例接受F-18-FAPI PET/CT成像的患者进行回顾性评估。根据标准化摄取值（SUVmax 和 SUVmean）对器官和良性病变示踪剂的摄取进行量化。我们比较了男性和女性之间某些器官示踪剂摄取的变化，分析了甲状腺弥漫性摄取的可能原因，并评估了不同月经周期阶段子宫示踪剂摄取的变化。还评估了良性病变中的偶然示踪剂摄取。结果 在泌尿道、胆道系统、颌下腺、胰腺、甲状腺、子宫、肠道、前列腺、腮腺、心肌、肾皮质和肌肉中观察到生理性 F-18-FAPI 摄取，但在脑、肺、肝脏、脾脏、结肠和乳房中未观察到。女性和男性每个器官的 SUV 平均值相似（所有 P > 0.05）。甲状腺中弥漫性示踪剂摄取是由正常甲状腺或甲状腺炎引起的；它们之间没有统计学上的显着差异（SUVmax：t = -1.3，P = 0.25；SUVmean：t = -1.1，P = 0.31）。不同月经周期阶段子宫摄取量存在显着差异（SUVmax：F = 5.08，P = 0.04；SUVmean：F = 5.19，P = 0.04）。在食管炎、甲状腺炎、关节炎、骨折和子宫肌瘤患者中观察到偶然的良性病变示踪剂摄取。结论本研究为相关器官及良性病变中F-18-FAPI的摄取提供了参考范围。良性病变 F-18-FAPI 摄取可能会降低 F-18-FAPI PET/CT 特异性。
Objective To systematically investigate the physiological distribution and benign lesion incidental uptake of (AlF)-F-18-NOTA-FAPI-04 (F-18-FAPI) in cancer patients to establish the normal uptake range in relevant organs and lesions. Methods Twenty patients who underwent F-18-FAPI PET/CT imaging were retrospectively assessed. Organ and benign lesion tracer uptake was quantified based on standardized uptake values (SUVmax and SUVmean). We compared the variation in tracer uptake in certain organs between men and women, analyzed the possible reasons for diffuse uptake in the thyroid, and assessed tracer uptake variations in the uterus in different menstrual cycle phases. Incidental tracer uptake in benign lesions was also assessed. Results Physiological F-18-FAPI uptake was observed in the urinary tract, biliary tract system, submandibular glands, pancreas, thyroid, uterus, intestine, prostate gland, parotid gland, myocardium, kidney cortex, and muscles, but not the brain, lungs, liver, spleen, colon, and breasts. The SUVmean for each organ was similar for women and men (all P > 0.05). Diffuse tracer uptake in the thyroid was caused by normal thyroid or thyroiditis; there were no statistically significant differences between them (SUVmax: t = -1.3, P = 0.25; SUVmean: t = -1.1, P = 0.31). There was a significant difference for uterus uptake among different menstrual cycle phases (SUVmax: F = 5.08, P = 0.04; SUVmean: F = 5.19, P = 0.04). Incidental benign lesion tracer uptake was observed in patients with esophagitis, thyroiditis, arthritis, fractures, and uterine fibroids. Conclusion This study provides a reference range for F-18-FAPI uptake in relevant organs and benign lesions. Benign lesion F-18-FAPI uptake may reduce F-18-FAPI PET/CT specificity.