A controlled clinical trial of alprazolam for the treatment of anxiety.
A controlled clinical trial of alprazolam for the treatment of anxiety.
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阿普唑仑治疗焦虑症的对照临床试验。
DOI：
10.1176/ajp.140.1.82
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Harris,H
中科院分区：
文献类型：
--
作者：
Rickels,K;Csanalosi,I;Greisman,P;Cohen,D;Werblowsky,J;Ross,HA;Harris,H
作者报告了一项大规模双盲研究的结果，该研究比较了阿普唑仑（一种三唑并苯二氮卓类药物）的抗焦虑作用；地西泮，一种 1, 4-苯二氮卓类药物；以及 151 名焦虑的门诊患者的安慰剂。阿普唑仑和地西泮产生了类似的临床改善，明显大于安慰剂产生的改善，并且仅在治疗 1 周后就明显明显。阿普唑仑的镇静发生率低于地西泮。
The authors report the results of a large-scale double-blind study comparing the anxiolytic effects of alprazolam, a triazolobenzodiazepine; diazepam, a 1, 4-benzodiazepine; and placebo in 151 anxious outpatients. Alprazolam and diazepam produced similar clinical improvement, which was significantly larger than improvement produced by placebo and was clearly evident after only 1 week of treatment. The incidence of sedation was lower with alprazolam than with diazepam.