Percutaneous pulmonary artery denentation completely abolishes experimental pulmonary arterial hypertension in vivo
Percutaneous pulmonary artery denentation completely abolishes experimental pulmonary arterial hypertension in vivo
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DOI：
10.4244/eijv9i2a43
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发表时间：
2013-06-01
期刊：
影响因子：
6.2
通讯作者：
Kwan, Tak W.
中科院分区：
文献类型：
--
作者：
Chen, Shao-Liang;Zhang, Yao-Jun;Kwan, Tak W.
目的：该研究旨在评估经皮肺动脉去神经（PADN）对球囊闭塞诱导的急性肺动脉高压（PAH）的影响。PADN是一种微创和血管内导管为基础的介入治疗，使用射频消融，以消除肺动脉压力感受器的压力response.Methods和结果：检查球囊闭塞引起的PAH的疗效，20只蒙古狗被随机分配到两组之一：组1（左肺远端基底干闭塞）和组2（左肺叶间动脉闭塞）。然后，在所有20只犬的左肺叶间动脉闭塞的情况下，在主肺动脉分叉水平进行PADN治疗。在基线和球囊闭塞期间以及PADN治疗期间的不同时间点（1、2、3、5和10分钟）测量血液动力学参数。在PADN治疗前，远端肺基底干闭塞组1的大多数肺动脉血流动力学参数保持不变。然而，在左肺叶间动脉闭塞的第2组中，平均肺动脉压、平均右心室压和肺血管阻力逐渐增加，平均绝对差在5分钟时达到峰值（分别为Delta 16.6 mmHg、Delta 14.1 mmHg和Delta 1，144 dye/s/cm（5）;
Aims: The study sought to assess the effect of percutaneous pulmonary artery denervation (PADN) on balloon-occlusion-induced acute pulmonary arterial hypertension (PAH) in vivo. The PADN is a minimally invasive and endovascular catheter-based interventional therapy using radiofrequency ablation to abolish the pulmonary arterial baroreceptors to pressure response.Methods and results: To examine the efficacy of balloon-occlusion-induced PAH, twenty Mongolian dogs were randomly assigned to one of two groups: group 1 (left distal pulmonary basal trunk occlusion) and group 2 (left pulmonary interlobar artery occlusion). Afterwards, PADN treatment at the main pulmonary artery bifurcation level with left pulmonary interlobar artery occlusion in all 20 dogs was conducted. Haemodynamic parameters were measured at baseline and during balloon occlusion as well as the PADN treatment at different time points: one, two, three, five, and ten minutes. Before the PADN treatment, most haemodynamic parameters of the pulmonary artery remained unchanged in group 1 with distal pulmonary basal trunk occlusion. However, in group 2 with the occlusion of the left pulmonary interlobar artery, mean pulmonary arterial pressure, mean right ventricular pressure, and pulmonary vessel resistance gradually increased, and mean absolute difference reached peak at five minutes (Delta 16.6 mmHg, Delta 14.1 mmHg and Delta 1,144 dye/s/cm(5), respectively; each p