Associations of blood levels of trace elements and heavy metals with metabolic syndrome in Chinese male adults with microRNA as mediators involved
Associations of blood levels of trace elements and heavy metals with metabolic syndrome in Chinese male adults with microRNA as mediators involved
复制标题
以microRNA为介质的中国男性成人血液微量元素和重金属水平与代谢综合征的关系
DOI：
10.1016/j.envpol.2019.02.015
复制
发表时间：
2019-05-01
影响因子：
8.9
通讯作者：
Gao, Ai
中科院分区：
文献类型：
--
作者：
Guo, Xiaoli;Yang, Qiaoyun;Gao, Ai
代谢综合征（MetS）是一个全球性的健康问题，其患病率日益增加。然而，微量元素和重金属对MetS的影响以及这种影响的机制知之甚少。2015年进行了初步的横断面研究。血铅（Pb），镉（Cd），铜（Cu），硒（Se）的浓度显着较高的MetS组中观察。根据年龄进行先验校正后，血液中铜和硒的浓度分别与MetS风险增加2.56倍[95%置信区间（CI），1.11，5.92]和3.31倍（95% CI，1.4，7.82）相关。此外，血硒浓度升高与体重指数（BMI）[比值比（OR）：2.56; 95%CI，1.11，5.93]、高血压[收缩压和舒张压]（收缩压和舒张压）;收缩压OR：3.82; 95% CI，1.47，7.31;舒张压OR：2.56; 95% CI，1.18，5.59]和高甘油三酯血症（OR：3.3; 95% CI，1.51，7.2）。此外，患有MetS的受试者中miR-21- 5 p、miR-122- 5 p和miR-146 a-5 p的表达显着高于未患有MetS的受试者。miR-21- 5 p表达增加与SBP（β = 5.28; 95% CI，0.63，9.94）和DBP（β =4.17; 95% CI，0.68，7.66）升高显著相关。此外，Cu与miR-21- 5 p正相关（β =3.02; 95%CI，0.07，5.95），而Se与miR-122- 5 p正相关（β =2.7; 95%CI，0.64，4.76）。Bootstrapping介导模型表明miR-21- 5 p部分介导了Cu水平与SBP/DBP的关系。本研究提示Cu和Se均与MetS相关，miR-215 p参与了与Cu相关的MetS的发生。(C)2019爱思唯尔有限公司版权所有。
Metabolic syndrome (MetS) is a global health problem with an increasing prevalence. However, effects of trace elements and heavy metals on MetS and the mechanism underlying this effect are poorly understood. A preliminary cross-sectional study was conducted in 2015. Significantly higher blood concentrations of lead (Pb), cadmium (Cd), copper (Cu), and selenium (Se) were observed in the MetS group. With a priori adjustment for age, the concentration of Cu and Se in the blood was associated with a 2.56 - fold [95% confidence interval (CI), 1.11, 5.92] and 3.31 - fold (95% CI, 1.4, 7.82) increased risk of MetS, respectively. Moreover, increased blood Se concentrations were associated with body mass index (BMI) [odds ratio (OR): 2.56; 95% Cl, 1.11, 5.93], high blood pressure [for both systolic and diastolic blood pressures (SBP and DBP); OR: 3.82; 95% CI, 1.47, 7.31 for SBP and OR: 2.56; 95% CI, 1.18, 5.59 for DBP], and hypertriglyceridemia (OR: 3.3; 95% CI, 1.51, 7.2). In addition, the expression of miR-21-5p, miR-122-5p, and miR-146a-5p was significantly higher in subjects with MetS than those without MetS. Increased expression of miR-21-5p was significantly associated with increased SBP (beta= 5.28; 95% CI, 0.63, 9.94) and DBP (beta=4.17; 95% Cl, 0.68, 7.66). Moreover, Cu was positively associated with miR-21-5p (beta=3.02; 95% CI, 0.07, 5.95), whereas Se was positively associated with miR-122-5p (beta=2.7; 95% CI, 0.64, 4.76). The bootstrapping mediation models indicated that miR-21-5p partially mediated the relationships between Cu level and SBP/DBP. This study suggested that Cu and Se were both associated with MetS, and miR-215p participated in the development of MetS associated with Cu. (C) 2019 Elsevier Ltd. All rights reserved.