Diagnosing and treating the failing right heart.
Diagnosing and treating the failing right heart.
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DOI：
10.1097/hco.0000000000000164
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发表时间：
2015-05
影响因子：
2.3
通讯作者：
Tedford RJ
中科院分区：
文献类型：
--
作者：
Ryan JJ;Tedford RJ
右心室衰竭（RVF）与显着的发病率和死亡率相关。人们对正确评估右心室 (RV) 功能以及了解 RVF 背后的机制越来越感兴趣。在这篇手稿中，我们讨论了 RV 中因 RVF 而发生的代谢变化，特别是向糖酵解和谷氨酰胺分解增加的转变。我们将详细介绍非侵入性成像在评估右心室功能方面取得的进展，并回顾评估右心室-肺动脉耦合的方法。最后，我们研究了新的治疗方案在 RV 衰竭中的作用，例如 β 受体阻滞剂治疗。 RVF 是一个复杂的实体。尽管可以根据 LV 对 RV 功能和治疗做出一些推论，但 RV 在解剖学、代谢和胚胎学方面具有独特的特征，这需要专门针对 RV 的研究。
Right ventricular failure (RVF) is associated with significant morbidity and mortality. There is an increasing interest in proper assessment of right ventricle (RV) function as well as understanding mechanisms behind RVF. Within this manuscript, we discuss the metabolic changes that occur in the RV that occur in response to RVF- in particular, a shift towards glycolysis and increased glutaminolysis. We will detail the advances made in non-invasive imaging in assessing the function of the RV and review the methods to assess right ventricle-pulmonary artery coupling. We lastly investigate the role of new treatment options in the failing RV, such as β-blocker therapy. RVF is a complicated entity. Although some inferences on RV function and treatment can be made from LV, the RV has unique features, anatomically, metabolically and embryologically, which requires dedicated RV-directed research.