Clinical significance of 18F-α-methyl tyrosine PET/CT for the detection of bone marrow invasion in patients with oral squamous cell carcinoma: comparison with 18F-FDG PET/CT and MRI
Clinical significance of 18F-α-methyl tyrosine PET/CT for the detection of bone marrow invasion in patients with oral squamous cell carcinoma: comparison with 18F-FDG PET/CT and MRI
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DOI：
10.1007/s12149-013-0701-0
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发表时间：
2013-06-01
影响因子：
2.6
通讯作者：
Tsushima, Yoshito
中科院分区：
文献类型：
--
作者：
Kim, Mai;Higuchi, Tetsuya;Tsushima, Yoshito
L-3-[F-18]-氟-α-甲基酪氨酸(F-18-FAMT)是一种用于正电子发射断层扫描/计算机断层扫描的氨基酸示踪剂，它通过L氨基酸转运蛋白1(LAT1)特异性地转运到癌细胞中。LAT1在肿瘤中的过度表达与细胞增殖和血管生成密切相关。比较F-18-FAMT PET/CT、F-18-氟代脱氧葡萄糖(F-18-FDG)PET/CT和磁共振成像(MRI)对口腔鳞状细胞癌(OSCC)骨髓侵犯的诊断价值。对27例上、下牙槽脊OSCC患者进行MRI、F-18-FDG和F-18-FAMT PET/CT分期。以术后病理检查为标准确定最终诊断。MRI、F-18-FDG PET/CT和F-18-FAMT PET/CT对骨髓侵犯的可能性一般以5分为标准。F-18-FDG PET/CT的敏感性(100%)高于MRI(95%)和F-18-FAMT PET/CT(90%)，F-18-FAMT PET/CT的特异性(85.7%)高于MRI(57%)和F-18-FDG PET/CT(14.3%)。病理肿瘤大小与F-18-FAMT PET/CT显示的肿瘤大小一致，小于F-18-FDG PET/CT显示的肿瘤大小(P<0.01)。F-18-FAMT PET/CT对口腔鳞癌骨髓侵犯的检测较MRI或F-18-FDG PET/CT更具特异性，有助于将口腔鳞癌的手术切除范围降至最低。
L-3-[F-18]-fluoro-alpha-methyl tyrosine (F-18-FAMT) is an amino acid tracer for positron emission tomography/computed tomography (PET/CT) which specifically transported into cancer cells by L-type amino acid transporter 1 (LAT1). LAT1 overexpression in tumors is significantly correlated with cell proliferation and angiogenesis. F-18-FAMT PET/CT, fluorine-18-fluorodeoxyglucose (F-18-FDG) PET/CT and magnetic resonance imaging (MRI) were compared for their diagnostic performance in the detection of bone marrow invasion in patients with oral squamous cell carcinoma (OSCC).Twenty-seven patients with OSCC on the upper or lower alveolar ridge underwent staging by MRI, F-18-FDG PET/CT and F-18-FAMT PET/CT studies before surgery. Post-surgical pathologic examination was used as the standard to determine the final diagnoses. The possibility of bone marrow invasion on MRI, F-18-FDG PET/CT and F-18-FAMT PET/CT were usually graded retrospectively into five-point score. Sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) were calculated according to the obtained scores.As the sensitivity of F-18-FDG PET/CT was highest (100 %) among that of MRI (95 %) and F-18-FAMT PET/CT (90 %), the specificity of F-18-FAMT PET/CT was highest (85.7 %) among that of MRI (57 %) and F-18-FDG PET/CT (14.3 %). The size of pathological tumor was accorded with that detected by F-18-FAMT PET/CT and was smaller than that detected by F-18-FDG PET/CT (P < 0.01). Significant difference was not found between F-18-FAMT PET tumor volume and pathological tumor volume.F-18-FAMT PET/CT was useful and more specific than MRI or F-18-FDG PET/CT in the detection of bone marrow invasion of OSCC and may contribute to minimize the extent of resection in oral surgery patient.