Effect of supplemental oxygen on supramaximal exercise performance and recovery in cystic fibrosis.
Effect of supplemental oxygen on supramaximal exercise performance and recovery in cystic fibrosis.
复制标题
补充氧气对超最大运动表现和囊性纤维化恢复的影响。
DOI：
10.1152/jappl.1997.83.5.1641
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Gozal,D
中科院分区：
文献类型：
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作者：
Shah,AR;Keens,TG;Gozal,D
Shah，Ashish R.，托马斯G. Keens和大卫Gozal。补充氧气对囊性纤维化患者超最大运动能力和恢复的影响。J。应用生理学。83（5）：1641-1647，1997。-补充O2对超极量运动后恢复和随后的表现的影响尚不清楚。如果慢性肺部疾病患者的运动恢复能力能够得到增强，那么随后的超极量运动表现也可以得到改善。对17名囊性纤维化（CF）患者[25 ± 10（SD）岁，53%男性，1 s用力呼气量= 62 ± 21%预测值]和17名正常受试者在呼吸100%O2或室内空气（RA）10 min后从超极量运动中恢复以及随后的超极量运动能力进行了评估（25 ± 8岁，59%为男性，1秒用力呼气量= 112 ± 15%预测值）。超极量性能被评估为在分级最大运动期间达到的最大负荷的130%的负荷下持续骑自行车的工作。CF患者在每一次超极量比赛结束时的峰值分钟通气量（V stece）和心率（HR）低于对照组。CF患者的单指数时间衰减常数表明HR恢复更快（RA和O2组的τHR分别为86 ± 8和73 ± 6 s，P< 0.01）。CF患者在吸氧时，最佳拟合呼吸恢复的双指数方程的快、慢时间常数也明显改善（分别为132.1 ± 10.5vs.82.5 ± 10.4s; 880.3 ± 300.1vs.368.6 ± 107.1s，P< 0.01）。然而，在控制方面没有出现这种改善。CF患者在O2后的超最大性能得到改善（O2后第一次发作的109 ± 6% vs. 94 ± 6%（P< 0.01）。补充O2对对照组随后的表现没有影响（O2组为97 ± 3%，对照组为97 ± 3%）。RA为93 ± 3%）。我们的结论是，补充O2后，一个短回合的超大运动加速恢复，并保留随后的超大性能CF患者。
Shah, Ashish R., Thomas G. Keens, and David Gozal.Effect of supplemental oxygen on supramaximal exercise performance and recovery in cystic fibrosis.J. Appl. Physiol.83(5): 1641–1647, 1997.—The effects of supplemental O2on recovery from supramaximal exercise and subsequent performance remain unknown. If recovery from exercise could be enhanced in individuals with chronic lung disease, subsequent supramaximal exercise performance could also be improved. Recovery from supramaximal exercise and subsequent supramaximal exercise performance were assessed after 10 min of breathing 100% O2or room air (RA) in 17 cystic fibrosis (CF) patients [25 ± 10 (SD) yr old, 53% men, forced expired volume in 1 s = 62 ± 21% predicted] and 17 normal subjects (25 ± 8 yr old, 59% men, forced expired volume in 1 s = 112 ± 15% predicted). Supramaximal performance was assessed as the work of sustained bicycling at a load of 130% of the maximum load achieved during a graded maximal exercise. Peak minute ventilation (V˙e) and heart rate (HR) were lower in CF patients at the end of each supramaximal bout than in controls. In CF patients, single-exponential time decay constants indicated faster recovery of HR (τHR= 86 ± 8 and 73 ± 6 s in RA and O2, respectively,P< 0.01). Similarly, fast and slow time constants of two-exponential equations providing the best fit for ventilatory recovery were improved in CF patients during O2breathing (= 132.1 ± 10.5 vs. 82.5 ± 10.4 s;= 880.3 ± 300.1 vs. 368.6 ± 107.1 s,P< 0.01). However, no such improvements occurred in controls. Supramaximal performance after O2improved in CF patients (109 ± 6% of the 1st bout after O2vs. 94 ± 6% in RA,P< 0.01). O2supplementation had no effect on subsequent performance in controls (97 ± 3% in O2vs. 93 ± 3% in RA). We conclude that supplemental O2after a short bout of supramaximal exercise accelerates recovery and preserves subsequent supramaximal performance in patients with CF.